NAFLD & Metabolic Liver Disease Protocol
NAFLD & Metabolic Liver Disease Protocol framework focused on consistent execution, practical monitoring, and safer progression.
A comprehensive protocol targeting non-alcoholic fatty liver disease and metabolic-associated steatohepatitis (MASH) through GLP-1 receptor agonism, AMPK activation, and mitochondrial support to reduce hepatic fat and inflammation.
Who it's for
Use this as an educational framework with clinical oversight. Keep timing consistent, track response daily, and change one variable at a time after trend review. Pair protocol use with sleep, nutrition, and recovery fundamentals.
Free Peptide Guide
NAFLD & Metabolic Liver Disease Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
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Protocol at a Glance
Cycle Duration
Minimum 24 weeks; monitor ALT, AST, liver ultrasound at 12-week intervals
Target Audience
Adults with confirmed NAFLD/MASH, elevated liver enzymes, or metabolic syndrome with hepatic steatosis
| Compound | Dose | Frequency |
|---|---|---|
| Semaglutide GLP-1 agonist; directly reduces hepatic steatosis, inflammation, and fibrosis markers in NASH trials | 0.25 mg escalating to 1–2.4 mg | Once weekly SC |
| Tirzepatide GLP-1/GIP dual agonist; superior hepatic fat reduction vs semaglutide alone in head-to-head studies | 2.5 mg escalating to 5–15 mg | Once weekly SC |
| AOD-9604 HGH fragment; activates fat-burning without growth effects; reduces visceral adiposity around liver | 300–600 mcg | Daily SC |
| AICAR AMPK activator; inhibits hepatic de novo lipogenesis and promotes fatty acid oxidation | 50–100 mg | Daily SC or oral |
| 5-Amino-1MQ NNMT inhibitor; elevates NAD+ in hepatic tissue, reduces lipid accumulation, improves mitochondrial function | 250 mg | Once daily oral |
| NAD+ Restores hepatic NAD+ levels; supports sirtuin-1 activity critical for fatty acid metabolism | 500 mg NMN or NR | Once daily oral |
Free Peptide Guide
NAFLD & Metabolic Liver Disease Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
Free access. No spam. This form sends the shared peptide guide that is live today.
Daily Schedule
Morning
Baseline review and first execution window
Log sleep, energy, and tolerance; complete planned Semaglutide timing if scheduled.
Midday
Adherence and symptom check
Review hydration, workload, and side effects before any changes.
Evening
Recovery closeout and next-day setup
Record outcomes, maintain schedule consistency, and prepare next-day protocol.
Safety
- Escalating side effects or new concerning symptoms require prompt clinical review.
- Avoid abrupt multi-compound changes during unstable periods.
- Maintain regular follow-up with a licensed clinician throughout the cycle.
Not appropriate for unsupervised use or as a replacement for diagnosis and medical care. Use only within a clinician-guided plan.
Who should avoid
- Anyone using this protocol without qualified medical supervision
- People with unstable medical or psychiatric conditions without specialist guidance
- Pregnant or breastfeeding individuals unless explicitly cleared by a physician
Common Mistakes
Changing multiple variables at once
Why it matters: This makes it hard to identify what improved outcomes versus what increased side effects.
How to fix: Keep one-variable changes per review cycle and log response for several days.
Ignoring adherence and recovery fundamentals
Why it matters: Protocol effectiveness drops when sleep, nutrition, and routine consistency are unstable.
How to fix: Protect daily anchors first, then optimize protocol details gradually.
FAQ
How long should NAFLD & Metabolic Liver Disease Protocol run before reassessment?
A common window is Minimum 24 weeks; monitor ALT, AST, liver ultrasound at 12-week intervals, with periodic review of tolerance and objective trends.
Can I increase complexity quickly for faster results?
Usually no. Safer optimization comes from staged changes and clear tracking.
What should I track each day?
Track schedule adherence, symptoms, sleep quality, and any adverse effects in one log.
Key Takeaways
- Consistency with Semaglutide + Tirzepatide execution matters more than frequent protocol changes.
- Single-variable adjustments improve safety and decision quality.
- Objective daily tracking supports better long-term outcomes.
Why This Stack Works
NAFLD/MASH is driven by insulin resistance, lipid accumulation, mitochondrial dysfunction, and hepatic inflammation. Semaglutide and Tirzepatide reduce hepatic fat through GLP-1/GIP receptor agonism, decreasing lipogenesis and promoting hepatocyte insulin sensitivity. AOD-9604 activates lipolysis pathways specifically targeting visceral adipose tissue adjacent to the liver. AICAR activates AMPK to stimulate hepatic fatty acid oxidation and inhibit de novo lipogenesis. 5-Amino-1MQ inhibits NNMT to shift metabolism toward NAD+-driven mitochondrial repair. NAD+ restores hepatic mitochondrial function and sirtuin-mediated lipid metabolism.
Clinical Research
No clinical references were provided for this stack yet.
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Medical disclaimer: This protocol is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.
Free Peptide Guide
NAFLD & Metabolic Liver Disease Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
Free access. No spam. This form sends the shared peptide guide that is live today.