CJC-1295
Also known as: CJC-1295 DAC, CJC-1295 No DAC, Modified GRF 1-29, Mod GRF 1-29, CJC 1295
CJC-1295 is a synthetic GHRH analog that stimulates the pituitary gland to produce and release growth hormone. The DAC (Drug Affinity Complex) version has a markedly extended half-life. The No DAC version (Modified GRF 1-29) preserves natural pulsatile GH release and is preferred in most protocols.
Half-Life
~30 minutes (No DAC) / 6–8 days (with DAC)
Route
SubQ
Category
Growth Hormone Peptides
Studies
26 references
Key Benefits
- Sustained increase in growth hormone levels
- Enhanced muscle growth and strength
- Improved fat metabolism and body composition
- Better recovery and tissue repair
- Increased bone density
- Enhanced immune function
- Improved skin quality and collagen production
- Synergistic GH release when combined with GHRPs like Ipamorelin
Mechanism of Action
CJC-1295 binds to GHRH receptors in the anterior pituitary gland, stimulating growth hormone secretion. The DAC version uses a drug affinity complex to bind to albumin in the bloodstream, extending half-life from ~30 minutes to 6–8 days. CJC-1295 No DAC preserves the natural pulsatile rhythm of GH release — important for maintaining insulin sensitivity and downstream benefits. Increased GH leads to elevated IGF-1 production by the liver.
Dosing Protocols
CJC-1295 No DAC (Preferred)
- Dose
- 100 mcg
- Frequency
- Once daily, before bed
- Timing
- Fasted — at least 2 hours after last meal and before eating
- Cycle
- 8–16 weeks, then 4 weeks off
Preserves natural pulsatile GH release. Often combined with Ipamorelin for synergistic effect. Take together in same injection window.
CJC-1295 with DAC
- Dose
- 1–2 mg
- Frequency
- Once per week
- Timing
- Any time; consistent weekly timing preferred
- Cycle
- 12–16 weeks, then 4 weeks off
Extended half-life provides continuous GH elevation. Less physiological than No DAC version. Some prefer this for convenience.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Water retention / puffiness
- Carpal tunnel syndrome (with prolonged use)
- Injection site irritation
- Hunger increase (minor)
- Fatigue during initial weeks
Contraindications
Active cancer or history of cancer. Pregnancy or breastfeeding. Uncontrolled diabetes or insulin resistance.
Storage
Lyophilized powder: store at −20°C. Reconstituted: refrigerate at 2–8°C, use within 30 days.
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Clinical Research
- 1.Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026ReviewPubMed Verified
- 2.Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al. · The American journal of sports medicine · 2026ReviewPubMed Verified
- 3.Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry
Uçaktürk E, Nemutlu E · Journal of pharmaceutical and biomedical analysis · 2026PubMed Verified
- 4.Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples
Thomas A, Walpurgis K, Thevis M · Journal of mass spectrometry : JMS · 2024PubMed Verified
- 5.Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples
Cristea CD, Radu M, Toboc A, Stan C, David V · Analytical biochemistry · 2023PubMed Verified
- 6.Probing for peptidic drugs (2-10 kDa) in doping control blood samples
Thomas A, Thilmany S, Hofmann A, Thevis M · Analytical science advances · 2022PubMed Verified
- 7.An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS
Coppieters G, Deventer K, Polet M, Van Eenoo P, Judák P · Journal of pharmaceutical and biomedical analysis · 2022PubMed Verified
- 8.Early detection of cannabinoids in biological samples based on their affinity interaction with the growth hormone secretagogue receptor
Danila GM, Puiu M, Zamfir LG, Bala C · Talanta · 2022PubMed Verified
- 9.Advances in the detection of growth hormone releasing hormone synthetic analogs
Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V · Drug testing and analysis · 2021PubMed Verified
- 10.Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry
Pont L, Alechaga É, Terrero A, Monfort N, Ventura R · Journal of chromatography. A · 2020PubMed Verified
- 11.A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS
Timms M, Ganio K, Steel R · Drug testing and analysis · 2019PubMed Verified
- 12.An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma
Timms M, Ganio K, Forbes G, Bailey S, Steel R · Drug testing and analysis · 2019PubMed Verified
- 13.The study of doping market: How to produce intelligence from Internet forums
Pineau T, Schopfer A, Grossrieder L, Broséus J, Esseiva P, Rossy Q · Forensic science international · 2016PubMed Verified
- 14.Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS
Knoop A, Thomas A, Fichant E, Delahaut P, Schänzer W, Thevis M · Analytical and bioanalytical chemistry · 2016PubMed Verified
- 15.Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions
Van Hout MC, Hearne E · Substance use & misuse · 2016ReviewPubMed Verified
- 16.Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS
Thomas A, Walpurgis K, Tretzel L, Brinkkötter P, Fichant E, Delahaut P et al. · Drug testing and analysis · 2015PubMed Verified
- 17.Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions
Thevis M, Thomas A, Schänzer W · Expert review of proteomics · 2014PubMed Verified
- 18.Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry
Kwok WH, Ho EN, Lau MY, Leung GN, Wong AS, Wan TS · Analytical and bioanalytical chemistry · 2013PubMed Verified
- 19.Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls
Thomas A, Schänzer W, Delahaut P, Thevis M · Methods (San Diego, Calif.) · 2012ReviewPubMed Verified
- 20.Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
Henninge J, Pepaj M, Hullstein I, Hemmersbach P · Drug testing and analysis · 2010PubMed Verified
- 21.Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009PubMed Verified
- 22.Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth
Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y et al. · Proceedings of the National Academy of Sciences of the United States of America · 2009PubMed Verified
- 23.Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Ionescu M, Frohman LA · The Journal of clinical endocrinology and metabolism · 2006Clinical TrialPubMed Verified
- 24.Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA et al. · American journal of physiology. Endocrinology and metabolism · 2006PubMed Verified
- 25.Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA · The Journal of clinical endocrinology and metabolism · 2006RCTPubMed Verified
- 26.Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I et al. · Endocrinology · 2005PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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