BPC-157

Key Benefits#

• Accelerates wound healing and tissue repair
• Reduces inflammation throughout the body
• Protects and heals the gastrointestinal tract
• Supports tendon and ligament healing
• Promotes bone and joint health
• May protect organs from toxins and injury
• Supports gut-brain axis function
• Counteracts NSAID-induced gut damage

Mechanism of Action#

BPC-157 promotes angiogenesis (formation of new blood vessels), accelerates wound healing, and protects organs by modulating growth factors and enhancing production of proteins involved in tissue repair. It demonstrates anti-inflammatory properties by regulating nitric oxide synthesis and promoting survival of damaged cells. It also activates the VEGF and FAK-paxillin signaling pathways critical for tissue regeneration.

Dosing Protocols#

Side Effects#

• Injection site discomfort
• Nausea (rare)
• Headache (rare)
• Dizziness (rare)

Contraindications#

Active cancer or personal history of cancer. Pregnancy or breastfeeding. Currently on blood thinners (consult physician).

Storage#

Lyophilized powder: store at −20°C. Reconstituted solution: refrigerate at 2–8°C, use within 30 days.

Featured In Stacks#

1. 1.
   Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review

   Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B et al. · Pharmaceuticals (Basel, Switzerland) · 2026ReviewPubMed Verified

2. 2.
   Conventional Antiarrhythmics Class I-IV, Late INa Inhibitors, IKs Enhancers, RyR2 Stabilizers, Gap Junction Modulators, Atrial-Selective Antiarrhythmics, and Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Therapy in Arrhythmias

   Sikiric P, Barisic I, Udovicic M, Lovric Bencic M, Balenovic D, Strinic D et al. · Pharmaceuticals (Basel, Switzerland) · 2026ReviewPubMed Verified

3. 3.
   Fourier Transform Infrared Spectroscopic Characterization of Aortic Wall Remodeling by Stable Gastric Pentadecapeptide BPC 157 After Unilateral Adrenalectomy in Rats

   Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O et al. · Pharmaceuticals (Basel, Switzerland) · 2026PubMed Verified

4. 4.
   Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System-Triple NO-Agent Approach in Rats

   Madzarac G, Becejac T, Penovic T, Drazenovic D, Kralj L, Popović Dolic M et al. · Pharmaceuticals (Basel, Switzerland) · 2026PubMed Verified

5. 5.
   Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

   Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026ReviewPubMed Verified

6. 6.
   Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians

   Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al. · The American journal of sports medicine · 2026ReviewPubMed Verified

7. 7.
   Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy

   Masnec S, Kokot A, Kralj T, Zlatar M, Loncaric K, Sablic M et al. · Pharmaceuticals (Basel, Switzerland) · 2025ReviewPubMed Verified

8. 8.
   Reply to Sikiric et al. BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on "Józwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. Pharmaceuticals 2025, 18, 185"

   Józwiak M, Bauer M, Kamysz W, Kleczkowska P · Pharmaceuticals (Basel, Switzerland) · 2025PubMed Verified

9. 9.
   BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on Józwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. Pharmaceuticals 2025, 18, 185

   Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al. · Pharmaceuticals (Basel, Switzerland) · 2025PubMed Verified

10. 10.
    Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing

    McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM · Current reviews in musculoskeletal medicine · 2025ReviewPubMed Verified

11. 11.
    Concerning BPC-157, a natural pentadecapeptide, that acts as a cytoprotectant and is believed to protect the gastro-intestinal tract (GIT)

    Whitehouse M · Inflammopharmacology · 2025PubMed Verified

12. 12.
    Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

    Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE et al. · HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025ReviewPubMed Verified

13. 13.
    Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System

    Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al. · Pharmaceuticals (Basel, Switzerland) · 2025ReviewPubMed Verified

14. 14.
    Acute Compartment Syndrome and Intra-Abdominal Hypertension, Decompression, Current Pharmacotherapy, and Stable Gastric Pentadecapeptide BPC 157 Solution

    Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al. · Pharmaceuticals (Basel, Switzerland) · 2025ReviewPubMed Verified

15. 15.
    Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study

    Lee E, Burgess K · Alternative therapies in health and medicine · 2025PubMed Verified

16. 16.
    Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review

    Józwiak M, Bauer M, Kamysz W, Kleczkowska P · Pharmaceuticals (Basel, Switzerland) · 2025ReviewPubMed Verified

17. 17.
    Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury

    Demirtaş H, Özer A, Yıldırım AK, Dursun AD, Sezen ŞC, Arslan M · Medicina (Kaunas, Lithuania) · 2025PubMed Verified

18. 18.
    Editorial Commentary: Testosterone, Growth Hormone, and Vitamin D Supplementation Is Not Routinely Indicated for Orthopaedic Surgery Patients

    Dekker TJ · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2025PubMed Verified

19. 19.
    Withdrawn: Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats

    Grubisic MM, Strbe S, Barisic I, Balenovic D, Stambolija V, Lozic M et al. · Current neuropharmacology · 2025PubMed Verified

20. 20.
    Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats

    Matek D, Matek I, Staresinic E, Japjec M, Bojanic I, Boban Blagaic A et al. · Pharmaceutics · 2025PubMed Verified

21. 21.
    Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado

    DiStefano MJ, Dardouri M, Moore GD, Saseen JJ, Nair KV · Journal of pharmaceutical policy and practice · 2025PubMed Verified

22. 22.
    Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study

    Lee E, Walker C, Ayadi B · Alternative therapies in health and medicine · 2024PubMed Verified

23. 23.
    Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance?

    DeFoor MT, Dekker TJ · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2025ReviewPubMed Verified

24. 24.
    Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A Review

    Bajramagic S, Sever M, Rasic F, Staresinic M, Skrtic A, Beketic Oreskovic L et al. · Pharmaceuticals (Basel, Switzerland) · 2024ReviewPubMed Verified

25. 25.
    New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection

    Sikiric P, Sever M, Krezic I, Vranes H, Kalogjera L, Smoday IM et al. · Inflammopharmacology · 2024ReviewPubMed Verified

26. 26.
    The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity

    Sikiric P, Boban Blagaic A, Strbe S, Beketic Oreskovic L, Oreskovic I, Sikiric S et al. · Pharmaceuticals (Basel, Switzerland) · 2024ReviewPubMed Verified

27. 27.
    From Selye's and Szabo's Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

    Sikiric P, Boban Blagaic A, Krezic I, Zizek H, Kalogjera L, Smoday IM et al. · Pharmaceuticals (Basel, Switzerland) · 2023ReviewPubMed Verified

28. 28.
    Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats

    Tepes M, Krezic I, Vranes H, Smoday IM, Kalogjera L, Zizek H et al. · Pharmaceuticals (Basel, Switzerland) · 2023PubMed Verified

29. 29.
    Stable Isotope Labeling-Based Nontargeted Strategy for Characterization of the In Vitro Metabolic Profile of a Novel Doping BPC-157 in Doping Control by UHPLC-HRMS

    Tian T, Jing J, Li Y, Wang Y, Deng X, Shan Y · Molecules (Basel, Switzerland) · 2023PubMed Verified

30. 30.
    Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats

    Smoday IM, Krezic I, Kalogjera L, Vukovic V, Zizek H, Skoro M et al. · Pharmaceuticals (Basel, Switzerland) · 2023PubMed Verified

31. 31.
    Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

    Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H et al. · World journal of gastroenterology · 2023PubMed Verified

32. 32.
    Stable Gastric Pentadecapeptide BPC 157-Possible Novel Therapy of Glaucoma and Other Ocular Conditions

    Sikiric P, Kokot A, Kralj T, Zlatar M, Masnec S, Lazic R et al. · Pharmaceuticals (Basel, Switzerland) · 2023ReviewPubMed Verified

33. 33.
    Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy

    Premuzic Mestrovic I, Smoday IM, Kalogjera L, Krezic I, Zizek H, Vranes H et al. · Pharmaceuticals (Basel, Switzerland) · 2023PubMed Verified

34. 34.
    Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

    Strbe S, Smoday IM, Krezic I, Kalogjera L, Vukovic V, Zizek H et al. · Pharmaceuticals (Basel, Switzerland) · 2023PubMed Verified

35. 35.
    Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function

    Sikiric P, Gojkovic S, Krezic I, Smoday IM, Kalogjera L, Zizek H et al. · Pharmaceuticals (Basel, Switzerland) · 2023ReviewPubMed Verified

36. 36.
    Duodenocolic fistula healing by pentadecapeptide BPC 157 in rats. A cytoprotection viewpoint

    Vukusic D, Zenko Sever A, Sever M, Drmic D, Milavic M, Sikiric S et al. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2024PubMed Verified

37. 37.
    Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs

    He L, Feng D, Guo H, Zhou Y, Li Z, Zhang K et al. · Frontiers in pharmacology · 2022PubMed Verified

38. 38.
    Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle

    Staresinic M, Japjec M, Vranes H, Prtoric A, Zizek H, Krezic I et al. · Biomedicines · 2022ReviewPubMed Verified

39. 39.
    Fourier Transform Infrared Spectroscopy Reveals Molecular Changes in Blood Vessels of Rats Treated with Pentadecapeptide BPC 157

    Gamulin O, Oroz K, Coric L, Krajacic M, Skrabic M, Dretar V et al. · Biomedicines · 2022PubMed Verified

40. 40.
    Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation

    Sikiric P, Udovicic M, Barisic I, Balenovic D, Zivanovic Posilovic G, Strinic D et al. · Biomedicines · 2022ReviewPubMed Verified

41. 41.
    Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro

    Huang BS, Huang SC, Chen FH, Chang Y, Mei HF, Huang HY et al. · Life sciences · 2022PubMed Verified

42. 42.
    Stable Gastric Pentadecapeptide BPC 157: Prompt Particular Activation of Collateral Pathways

    Sikiric P, Gojkovic S, Knezevic M, Tepes M, Strbe S, Vukojevic J et al. · Current medicinal chemistry · 2023PubMed Verified

43. 43.
    BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling "Negative-Like" Symptoms of Schizophrenia

    Zemba Cilic A, Zemba M, Cilic M, Strbe S, Ilic S, Vukojevic J et al. · Biomedicines · 2022PubMed Verified

44. 44.
    Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats

    Smoday IM, Petrovic I, Kalogjera L, Vranes H, Zizek H, Krezic I et al. · Biomedicines · 2022PubMed Verified

45. 45.
    Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy

    Perovic D, Milavic M, Dokuzovic S, Krezic I, Gojkovic S, Vranes H et al. · Current issues in molecular biology · 2022PubMed Verified

46. 46.
    Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N(G)-nitro-L-arginine methyl ester worsening

    Bilic Z, Gojkovic S, Kalogjera L, Krezic I, Malekinusic D, Knezevic M et al. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2021PubMed Verified

47. 47.
    The anti-nociceptive effect of BPC-157 on the incisional pain model in rats

    Jung YH, Kim H, Kim H, Kim E, Baik J, Kang H · Journal of dental anesthesia and pain medicine · 2022PubMed Verified

48. 48.
    Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats

    Barisic I, Balenovic D, Udovicic M, Bardak D, Strinic D, Vlainić J et al. · Biomedicines · 2022PubMed Verified

49. 49.
    Corrigendum: Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats

    Tepes M, Gojkovic S, Krezic I, Zizek H, Vranes H, Madzar Z et al. · Frontiers in pharmacology · 2021PubMed Verified

50. 50.
    Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome

    Sikiric P, Skrtic A, Gojkovic S, Krezic I, Zizek H, Lovric E et al. · World journal of gastroenterology · 2022PubMed Verified