5-Amino-1MQ
Also known as: 5-Amino-1-methylquinolinium, 5A1MQ
5-Amino-1MQ is a small-molecule NNMT (Nicotinamide N-methyltransferase) inhibitor that raises intracellular NAD+ levels and promotes fat burning. It is notable for targeting adipose tissue directly, reducing fat cell size and number while increasing metabolic rate.
Half-Life
Estimated 4–8 hours
Route
Oral
Category
Fat Loss & Metabolic
Studies
3 references
Key Benefits
- Raises intracellular NAD+ levels
- Directly targets adipose tissue for fat reduction
- Reduces fat cell size and differentiation
- Increases basal metabolic rate
- SIRT1 activation for metabolic regulation
- No stimulant cardiovascular side effects
- Synergistic with intermittent fasting and caloric restriction
- May have anti-aging metabolic benefits
Mechanism of Action
5-Amino-1MQ inhibits NNMT (Nicotinamide N-methyltransferase), an enzyme in adipose tissue that consumes SAM (S-adenosylmethionine) and depletes cellular NAD+. By blocking NNMT, it raises intracellular NAD+ levels in fat cells, activating SIRT1 and downstream pathways that promote fat oxidation. Studies show it reduces adipocyte differentiation, decreases fat cell lipid content, and increases resting metabolic rate without stimulant effects.
Dosing Protocols
Standard Fat Loss Protocol
- Dose
- 50–100 mg
- Frequency
- Once to twice daily
- Timing
- With or without food
- Cycle
- 8–12 weeks
Oral capsules. Well-tolerated in available research. May be stacked with other metabolic peptides/compounds. Limited long-term human data.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally well-tolerated in available studies
- Mild GI discomfort (rare)
- Limited long-term human data
Contraindications
Pregnancy or breastfeeding. Limited human safety data.
Storage
Store oral capsules at room temperature away from moisture and heat.
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Clinical Research
- 1.NAD(+) metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer
Yang M, Wang B, Hou W, Zeng H, He W, Zhang XK et al. · Journal for immunotherapy of cancer · 2024PubMed Verified
- 2.Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T et al. · Scientific reports · 2022PubMed Verified
- 3.Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells
Akar S, Duran T, Azzawri AA, Koçak N, Çelik Ç, Yıldırım Hİ · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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