NAD+

Key Benefits#

• Restored cellular energy production (ATP)
• Sirtuin activation for longevity and metabolic regulation
• Enhanced DNA repair capacity
• Improved mitochondrial function and biogenesis
• Cognitive clarity and mental energy
• Reduced inflammation
• Addiction withdrawal support (opioids, alcohol, benzodiazepines)
• Improved sleep quality
• Enhanced athletic endurance

Mechanism of Action#

NAD+ is an essential coenzyme in hundreds of metabolic reactions, serving as an electron carrier in cellular respiration. It activates sirtuins (SIRT1-7) — longevity enzymes that regulate gene expression, DNA repair, and mitochondrial function. NAD+ also activates PARP enzymes for DNA damage repair and CD38/ADPRC for cell signaling. Levels decline ~50% between age 40 and 60, contributing to metabolic dysfunction, reduced energy, and impaired DNA repair. IV administration bypasses gut absorption limitations.

Dosing Protocols#

Side Effects#

• Flushing and warmth during IV infusion
• Nausea during rapid IV administration
• Chest tightness (from rapid infusion — slow the rate)
• Injection site irritation (subcutaneous)
• Headache

Contraindications#

Active cancer (NAD+ supports DNA repair which may benefit cancer cells — theoretical concern). Pregnancy or breastfeeding (insufficient data).

Storage#

IV solution: refrigerate, protect from light, use immediately after preparation. Lyophilized: store at −20°C. Oral capsules: room temperature away from heat and moisture.

Featured In Stacks#

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