Glutathione vs Pinealon
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & LongevityImmune Support
GlutathioneCognitive EnhancementAnti-Aging & Longevity
Pinealon- Summary
- Glutathione is the body's master endogenous antioxidant tripeptide, composed of glutamate, cysteine, and glycine. It neutralizes reactive oxygen species, supports detoxification in the liver, recycles other antioxidants (vitamins C and E), and plays a central role in immune function, DNA repair, and cellular redox balance.
- Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the St. Petersburg Institute of Bioregulation, designed to penetrate the blood-brain barrier and exert neuroprotective, neurogenic, and anti-aging effects by regulating pineal gland and brain cell function.
- Half-Life
- Minutes to hours depending on route; IV half-life approximately 10-30 minutes
- Short (peptides rapidly degraded), but epigenetic/gene regulatory effects persist
- Admin Route
- Oral (liposomal preferred), Sublingual, Intravenous, Nebulized/inhaled, Topical
- SubQ, Oral, Intranasal
- Research
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- Typical Dose
- 250-1000 mg per day
- 5–10 mg (oral) or 50–100 mcg (SC)
- Frequency
- Once or twice daily
- Once daily for 10 days
- Key Benefits
- Primary endogenous antioxidant and free radical scavenger
- Supports hepatic detoxification of xenobiotics and heavy metals
- Recycles vitamins C and E to maintain antioxidant network
- Modulates immune function and T-cell activity
- Skin brightening via inhibition of tyrosinase (IV/topical routes)
- Neuroprotective in oxidative stress-related conditions
- Mitochondrial protection and energy metabolism support
- Neuroprotection against oxidative stress and hypoxia
- Promotes neuronal regeneration and repair
- Improves memory and cognitive function
- Enhances sleep quality via melatonin regulation
- Anti-aging effects on brain cells
- May slow cognitive decline in neurodegeneration
- Improves cerebrovascular circulation
- Reduces neuroinflammation
- Side Effects
- Oral bioavailability is limited (largely hydrolyzed in gut); liposomal or sublingual forms preferred
- IV administration: rare allergic reactions, vein irritation
- High-dose supplementation may cause zinc depletion over time
- Inhaled glutathione may trigger bronchoconstriction in asthmatics
- Excellent safety profile in clinical use
- Rare: mild drowsiness
- Transient mild headache at initiation
- Injection site reaction (SC)
- Stacks With
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