Pinealon

Key Benefits#

• Neuroprotection against oxidative stress and hypoxia
• Promotes neuronal regeneration and repair
• Improves memory and cognitive function
• Enhances sleep quality via melatonin regulation
• Anti-aging effects on brain cells
• May slow cognitive decline in neurodegeneration
• Improves cerebrovascular circulation
• Reduces neuroinflammation

Mechanism of Action#

Pinealon is a short regulatory peptide that acts as a gene expression modulator in neuronal and glial cells. It penetrates the blood-brain barrier due to its small size and interacts with chromatin (DNA-histone complexes) in neurons, activating expression of antioxidant enzymes, BDNF, and neuroprotective proteins. It modulates pineal gland activity, enhancing melatonin secretion and resetting circadian rhythms. Pinealon also exhibits anti-apoptotic effects in neurons exposed to hypoxia or oxidative stress, and may normalize neurotransmitter balance in aging brains.

Dosing Protocols#

Side Effects#

• Excellent safety profile in clinical use
• Rare: mild drowsiness
• Transient mild headache at initiation
• Injection site reaction (SC)

Contraindications#

No significant contraindications identified. Use with caution in pregnancy/lactation (insufficient data). Avoid concurrent use with strong CNS medications without medical supervision.

Storage#

Store at room temperature or refrigerated (4°C) in airtight container. Protect from moisture and light. Oral capsules: 24 months shelf life.

Featured In Stacks#

1. 1.
   Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

   Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026ReviewPubMed Verified

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   Optimization of Jiuzao protein hydrolysis conditions and antioxidant activity in vivo of Jiuzao tetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway

   Jiang Y, Wang R, Yin Z, Sun J, Wang B, Zhao D et al. · Food & function · 2021PubMed Verified

3. 3.
   EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease

   Khavinson V, Linkova N, Kozhevnikova E, Trofimova S · Molecules (Basel, Switzerland) · 2020ReviewPubMed Verified

4. 4.
   Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction

   Silanteva IA, Komolkin AV, Morozova EA, Vorontsov-Velyaminov PN, Kasyanenko NA · The journal of physical chemistry. B · 2019PubMed Verified

5. 5.
   Short peptides stimulate serotonin expression in cells of brain cortex

   Khavinson VKh, Lin'kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO · Bulletin of experimental biology and medicine · 2014PubMed Verified

6. 6.
   Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats

   Voicekhovskaya MA, Chalisova NI, Kontsevaya EA, Ryzhak GA · Bulletin of experimental biology and medicine · 2012PubMed Verified

7. 7.
   Effect of short peptides on expression of signaling molecules in organotypic pineal cell culture

   Khavinson VKh, Linkova NS, Chalisova NI, Dudkov AV, Koncevaya EA · Bulletin of experimental biology and medicine · 2011PubMed Verified

8. 8.
   Pinealon protects the rat offspring from prenatal hyperhomocysteinemia

   Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V · International journal of clinical and experimental medicine · 2012PubMed Verified

9. 9.
   Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

   Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF · Biochemistry. Biokhimiia · 2011PubMed Verified

10. 10.
    Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes

    Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A et al. · Rejuvenation research · 2011PubMed Verified