Glutathione vs NAD+
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & LongevityImmune Support
GlutathioneAnti-Aging & Longevity
NAD+- Summary
- Glutathione is the body's master endogenous antioxidant tripeptide, composed of glutamate, cysteine, and glycine. It neutralizes reactive oxygen species, supports detoxification in the liver, recycles other antioxidants (vitamins C and E), and plays a central role in immune function, DNA repair, and cellular redox balance.
- NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that declines dramatically with age. It is critical for energy metabolism, DNA repair, and sirtuin activation. IV and subcutaneous NAD+ supplementation is used in anti-aging protocols and addiction recovery programs.
- Half-Life
- Minutes to hours depending on route; IV half-life approximately 10-30 minutes
- Varies by route; IV provides direct cellular delivery
- Admin Route
- Oral (liposomal preferred), Sublingual, Intravenous, Nebulized/inhaled, Topical
- IV, SubQ, Oral
- Research
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- Typical Dose
- 250-1000 mg per day
- 500–1000 mg
- Frequency
- Once or twice daily
- Daily for 4–10 days (loading), then monthly maintenance
- Key Benefits
- Primary endogenous antioxidant and free radical scavenger
- Supports hepatic detoxification of xenobiotics and heavy metals
- Recycles vitamins C and E to maintain antioxidant network
- Modulates immune function and T-cell activity
- Skin brightening via inhibition of tyrosinase (IV/topical routes)
- Neuroprotective in oxidative stress-related conditions
- Mitochondrial protection and energy metabolism support
- Restored cellular energy production (ATP)
- Sirtuin activation for longevity and metabolic regulation
- Enhanced DNA repair capacity
- Improved mitochondrial function and biogenesis
- Cognitive clarity and mental energy
- Reduced inflammation
- Addiction withdrawal support (opioids, alcohol, benzodiazepines)
- Improved sleep quality
- Enhanced athletic endurance
- Side Effects
- Oral bioavailability is limited (largely hydrolyzed in gut); liposomal or sublingual forms preferred
- IV administration: rare allergic reactions, vein irritation
- High-dose supplementation may cause zinc depletion over time
- Inhaled glutathione may trigger bronchoconstriction in asthmatics
- Flushing and warmth during IV infusion
- Nausea during rapid IV administration
- Chest tightness (from rapid infusion — slow the rate)
- Injection site irritation (subcutaneous)
- +1 more
- Stacks With
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