ME/CFS & Chronic Fatigue Recovery Protocol
ME/CFS & Chronic Fatigue Recovery Protocol framework focused on consistent execution, practical monitoring, and safer progression.
A protocol targeting the core pathophysiological mechanisms of ME/CFS and chronic fatigue syndrome: mitochondrial dysfunction, neuroinflammation, immune dysregulation, and HPA axis dysregulation.
Who it's for
Use this as an educational framework with clinical oversight. Keep timing consistent, track response daily, and change one variable at a time after trend review. Pair protocol use with sleep, nutrition, and recovery fundamentals.
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ME/CFS & Chronic Fatigue Recovery Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
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Protocol at a Glance
Cycle Duration
3–6 months minimum; reassess every 8 weeks
Target Audience
Individuals diagnosed with ME/CFS, Long COVID fatigue syndrome, or chronic unexplained fatigue
| Compound | Dose | Frequency |
|---|---|---|
| SS-31 (Elamipretide) SS-31 as primary mitochondrial protectant — restoring electron transport chain efficiency | 2 mg | Daily |
| MOTS-c MOTS-c for mitochondrial biogenesis, AMPK activation, and metabolic flexibility restoration | 5 mg | 3x/week |
| ARA-290 ARA-290 for small fiber neuropathy, neuroinflammation, and post-exertional malaise mechanisms | 4 mcg/kg | 3x/week |
| Selank Selank for HPA axis normalization, reducing immunological hyperactivation and anxiety | 250 mcg | Twice daily |
| Thymosin Alpha-1 Thymosin Alpha-1 for immune modulation — restoring balanced immune function | 1.6 mg | Daily |
| DSIP DSIP to restore normal sleep architecture and HGH recovery cycles | 100 mcg | Nightly |
Free Peptide Guide
ME/CFS & Chronic Fatigue Recovery Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
Free access. No spam. This form sends the shared peptide guide that is live today.
Daily Schedule
Morning
Baseline review and first execution window
Log sleep, energy, and tolerance; complete planned SS-31 (Elamipretide) timing if scheduled.
Midday
Adherence and symptom check
Review hydration, workload, and side effects before any changes.
Evening
Recovery closeout and next-day setup
Record outcomes, maintain schedule consistency, and prepare next-day protocol.
Safety
- Escalating side effects or new concerning symptoms require prompt clinical review.
- Avoid abrupt multi-compound changes during unstable periods.
- Maintain regular follow-up with a licensed clinician throughout the cycle.
Not appropriate for unsupervised use or as a replacement for diagnosis and medical care. Use only within a clinician-guided plan.
Who should avoid
- Anyone using this protocol without qualified medical supervision
- People with unstable medical or psychiatric conditions without specialist guidance
- Pregnant or breastfeeding individuals unless explicitly cleared by a physician
Common Mistakes
Changing multiple variables at once
Why it matters: This makes it hard to identify what improved outcomes versus what increased side effects.
How to fix: Keep one-variable changes per review cycle and log response for several days.
Ignoring adherence and recovery fundamentals
Why it matters: Protocol effectiveness drops when sleep, nutrition, and routine consistency are unstable.
How to fix: Protect daily anchors first, then optimize protocol details gradually.
FAQ
How long should ME/CFS & Chronic Fatigue Recovery Protocol run before reassessment?
A common window is 3–6 months minimum; reassess every 8 weeks, with periodic review of tolerance and objective trends.
Can I increase complexity quickly for faster results?
Usually no. Safer optimization comes from staged changes and clear tracking.
What should I track each day?
Track schedule adherence, symptoms, sleep quality, and any adverse effects in one log.
Key Takeaways
- Consistency with SS-31 (Elamipretide) + MOTS-c execution matters more than frequent protocol changes.
- Single-variable adjustments improve safety and decision quality.
- Objective daily tracking supports better long-term outcomes.
Why This Stack Works
ME/CFS involves a complex intersection of mitochondrial energy failure, neuroinflammatory damage, immune overactivation and exhaustion, and hypothalamic dysfunction. SS-31 directly addresses the mitochondrial dysfunction — specifically the cardiolipin oxidation that impairs electron transport chain efficiency. MOTS-c restores mitochondrial signaling and metabolic flexibility. ARA-290 tackles the small fiber neuropathy and neuroinflammation that underlies post-exertional malaise. Selank normalizes HPA axis function and reduces the immunological hyperactivation. Thymosin Alpha-1 restores immune balance.
Clinical Research
No clinical references were provided for this stack yet.
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Medical disclaimer: This protocol is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.
Free Peptide Guide
ME/CFS & Chronic Fatigue Recovery Protocol Protocol PDF
Schedule template, practical checkpoints, common mistakes, and safety guidance in one quick reference.
Free access. No spam. This form sends the shared peptide guide that is live today.