Thymulin vs Dermorphin
Side-by-side comparison of key properties, dosing, and research.
Immune Support
ThymulinRecovery & Repair
Dermorphin- Summary
- Thymulin is a nonapeptide hormone produced exclusively by the thymic epithelium. It requires zinc for biological activity and plays a critical role in T-lymphocyte maturation, differentiation, and immune regulation. Thymulin levels decline dramatically with age, contributing to immunosenescence.
- Dermorphin is a naturally occurring heptapeptide opioid isolated from the skin of South American phyllomedusine frogs. It is one of the most potent endogenous mu-opioid receptor agonists known, approximately 30-40 times more potent than morphine by weight. Explored for pain management and fatigue modulation.
- Half-Life
- ~30 minutes active half-life
- Estimated 30-60 minutes (longer than endorphins due to D-Ala)
- Admin Route
- SubQ
- Subcutaneous (research), Intrathecal (research), Intranasal (research)
- Research
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- Typical Dose
- 20-30 mcg
- Not established for human use; research doses vary widely
- Frequency
- 10 days per month (Khavinson protocol)
- Not established
- Key Benefits
- Enhances T-cell maturation and differentiation
- Boosts NK cell cytotoxic activity
- Reduces inflammatory cytokine production (TNF-α, IL-1)
- Anti-nociceptive (pain-reducing) properties
- Restores age-related immune decline
- Anti-inflammatory via serotonin pathway modulation
- Potent analgesia superior to morphine on a per-weight basis
- May reduce perception of fatigue in high-intensity activity
- Longer-lasting than endogenous opioids due to D-amino acid substitution
- Research tool for mu-opioid receptor pharmacology
- Potential therapeutic application in refractory pain
- Side Effects
- Injection site reactions
- Mild fatigue initially as immune system activates
- High addiction and dependence potential (mu-opioid agonism)
- Respiratory depression at high doses
- Nausea, vomiting, constipation
- Sedation and cognitive impairment
- +2 more
- Stacks With
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