Spermidine vs Ipamorelin
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & LongevityCognitive Enhancement
SpermidineGrowth Hormone Peptides
Ipamorelin- Summary
- Spermidine is a naturally occurring polyamine found in all living cells, with exceptionally high concentrations in wheat germ, aged cheese, and human sperm. It is the most studied autophagy-inducing dietary compound, shown to extend lifespan across multiple species and reduce cardiovascular and cognitive aging.
- Ipamorelin is a selective GHRP (growth hormone releasing peptide) and one of the cleanest GH secretagogues available. It selectively stimulates GH release without significantly raising cortisol, prolactin, or appetite — making it ideal for long-term use and anti-aging protocols.
- Half-Life
- ~30–60 minutes, but gut bacteria produce it continuously; supplementation raises tissue levels over weeks
- 2 hours
- Admin Route
- Oral
- SubQ
- Research
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- Typical Dose
- 1–5 mg
- 100–300 mcg
- Frequency
- Once daily
- Once to twice daily
- Key Benefits
- Induces autophagy — cellular self-cleaning
- Extends lifespan in yeast, flies, worms, and mice
- Reduces cardiovascular aging and arterial stiffness
- Reduces all-cause mortality (human epidemiological data)
- Neuroprotective: reduces amyloid and tau pathology
- Promotes hair growth (anagen phase activation)
- Reduces age-related immune decline
- Improves memory in aging models
- Increases lean muscle mass
- Enhances fat loss
- Improves recovery time
- Strengthens bones and joints
- Better sleep quality and REM sleep
- Enhanced skin elasticity
- Minimal impact on hunger or cortisol
- No cortisol or prolactin spike
- Clean GH release suitable for long-term protocols
- Side Effects
- Generally very well tolerated
- Rare: mild GI discomfort at high doses
- May temporarily reduce some gut bacteria species
- Rare: headache at initiation
- Injection site irritation
- Temporary water retention (mild)
- Possible hunger increase (milder than GHRP-6)
- Numbness or tingling in extremities (rare)
- Stacks With
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