Palmitoyl Tetrapeptide-7 vs Spermidine
Side-by-side comparison of key properties, dosing, and research.
Skin & Cosmetic
Palmitoyl Tetrapeptide-7Anti-Aging & LongevityCognitive Enhancement
Spermidine- Summary
- Palmitoyl Tetrapeptide-7 (Rigin) is a cosmetic peptide consisting of palmitic acid linked to the tetrapeptide sequence GQPR (Gly-Gln-Pro-Arg). It was designed to mimic the biological activity of the IgG immunoglobulin C-terminus, which downregulates the production of interleukin-6 (IL-6), a key driver of skin aging and inflammation.
- Spermidine is a naturally occurring polyamine found in all living cells, with exceptionally high concentrations in wheat germ, aged cheese, and human sperm. It is the most studied autophagy-inducing dietary compound, shown to extend lifespan across multiple species and reduce cardiovascular and cognitive aging.
- Half-Life
- Topical penetration-dependent; effects last hours to days
- ~30–60 minutes, but gut bacteria produce it continuously; supplementation raises tissue levels over weeks
- Admin Route
- Topical
- Oral
- Research
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- Typical Dose
- 2-5 ppm concentration in formulation
- 1–5 mg
- Frequency
- Twice daily
- Once daily
- Key Benefits
- Reduces IL-6 inflammatory cytokine in skin
- Prevents 'inflammaging' of the skin
- Inhibits MMP collagen-degrading enzymes
- Synergistic with Matrixyl for anti-aging
- Clinically tested for wrinkle and skin texture improvement
- Well-tolerated topically
- Induces autophagy — cellular self-cleaning
- Extends lifespan in yeast, flies, worms, and mice
- Reduces cardiovascular aging and arterial stiffness
- Reduces all-cause mortality (human epidemiological data)
- Neuroprotective: reduces amyloid and tau pathology
- Promotes hair growth (anagen phase activation)
- Reduces age-related immune decline
- Improves memory in aging models
- Side Effects
- Contact sensitization (rare)
- Well-tolerated at standard concentrations
- Generally very well tolerated
- Rare: mild GI discomfort at high doses
- May temporarily reduce some gut bacteria species
- Rare: headache at initiation
- Stacks With
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