Humanin vs Sermorelin
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & Longevity
HumaninGrowth Hormone PeptidesAnti-Aging & Longevity
Sermorelin- Summary
- Humanin is a mitochondria-derived peptide (MDP) encoded in the 16S rRNA region of the mitochondrial genome. It protects neurons and other cells from apoptosis, improves insulin sensitivity, and declines significantly with age. HNG (S14G-Humanin) is a synthetic analog with 1000x greater potency.
- Sermorelin is a bioidentical synthetic peptide comprising the first 29 amino acids of naturally occurring GHRH. It is FDA-approved for diagnostic use and widely prescribed off-label for anti-aging, stimulating growth hormone production in a natural pulsatile pattern that mimics the body's own rhythm.
- Half-Life
- ~4–8 hours (HNG)
- 10–20 minutes
- Admin Route
- SubQ
- SubQ
- Research
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- Typical Dose
- 2–8 mg
- 200–500 mcg
- Frequency
- 3–5 times per week
- 5–7 days per week
- Key Benefits
- Neuroprotection against amyloid-beta toxicity (Alzheimer's relevance)
- Inhibits cellular apoptosis
- Improves insulin sensitivity
- Reduces cardiovascular risk markers
- Anti-inflammatory effects
- Correlates with longevity in centenarian studies
- Protects against ischemic injury
- Potential cancer cell apoptosis sensitization
- Increases energy and vitality
- Improves body composition (more muscle, less fat)
- Enhances skin thickness and elasticity
- Strengthens immune system
- Improves sleep quality and REM sleep
- Supports bone density
- Enhances mental clarity and focus
- Safer than exogenous HGH — respects natural feedback loops
- FDA-approved for GH diagnostic use
- Side Effects
- Injection site irritation
- Limited human safety data available
- Injection site irritation
- Flushing
- Headache
- Dizziness
- +2 more
- Stacks With
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