Sermorelin

Key Benefits#

• Increases energy and vitality
• Improves body composition (more muscle, less fat)
• Enhances skin thickness and elasticity
• Strengthens immune system
• Improves sleep quality and REM sleep
• Supports bone density
• Enhances mental clarity and focus
• Safer than exogenous HGH — respects natural feedback loops
• FDA-approved for GH diagnostic use

Mechanism of Action#

Sermorelin binds to GHRH receptors in the anterior pituitary gland, stimulating natural pulsatile growth hormone production and release. As a bioidentical GHRH fragment, it works through the body's own feedback mechanisms — it cannot overstimulate GH production beyond natural physiological levels. This safety profile distinguishes it from exogenous HGH injection.

Dosing Protocols#

Side Effects#

• Injection site irritation
• Flushing
• Headache
• Dizziness
• Nausea (rare)
• Swelling at injection site

Contraindications#

Active cancer or history of cancer. Pregnancy or breastfeeding. Untreated hypothyroidism (thyroid function should be optimized before use).

Storage#

Lyophilized powder: store at −20°C. Reconstituted: refrigerate at 2–8°C, use within 30 days.

Featured In Stacks#

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   Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

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   Uçaktürk E, Nemutlu E · Journal of pharmaceutical and biomedical analysis · 2026PubMed Verified

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   Growth hormone - releasing hormone antagonists induce autophagy in cancer cells

   Sigdel M, Fakir S, Sarker MMR, Barabutis N · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2025PubMed Verified

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   Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells

   Gesmundo I, Pedrolli F, Giglioli FR, Jazaj F, Granato G, Bertoldo A et al. · International journal of molecular sciences · 2025PubMed Verified

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   Antagonist of Growth Hormone-Releasing Hormone Receptor MIA-690 Suppresses the Growth of Androgen-Independent Prostate Cancers

   Muñoz-Moreno L, Gómez-Calcerrada MI, Arenas MI, Carmena MJ, Prieto JC, Schally AV et al. · International journal of molecular sciences · 2024PubMed Verified

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   A novel approach for the treatment of AML, through GHRH antagonism: MIA-602

   Costoya J, Gaumond SI, Chale RS, Schally AV, Jimenez JJ · Reviews in endocrine & metabolic disorders · 2025ReviewPubMed Verified

7. 7.
   Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia

   Gaumond SI, Abdin R, Costoya J, Schally AV, Jimenez JJ · Oncotarget · 2024PubMed Verified

8. 8.
   Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples

   Thomas A, Walpurgis K, Thevis M · Journal of mass spectrometry : JMS · 2024PubMed Verified

9. 9.
   Growth hormone-releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice

   Condor Capcha JM, Kamiar A, Robleto E, Saad AG, Cui T, Wong A et al. · Proceedings of the National Academy of Sciences of the United States of America · 2023PubMed Verified

10. 10.
    Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples

    Cristea CD, Radu M, Toboc A, Stan C, David V · Analytical biochemistry · 2023PubMed Verified

11. 11.
    In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides

    González-López NM, Guerra-Acero-Turizo LM, Blanco-Medina I, Barragán-Cárdenas AC, Ramírez-Celis DA, Martínez-Ramírez JA et al. · Biomedical chromatography : BMC · 2023PubMed Verified

12. 12.
    Growth hormone-releasing hormone antagonist MIA-602 inhibits inflammation induced by SARS-CoV-2 spike protein and bacterial lipopolysaccharide synergism in macrophages and human peripheral blood mononuclear cells

    Granato G, Gesmundo I, Pedrolli F, Kasarla R, Begani L, Banfi D et al. · Frontiers in immunology · 2023PubMed Verified

13. 13.
    GHRH agonist MR-409 protects β-cells from streptozotocin-induced diabetes

    Louzada RA, Blandino-Rosano M, Flores S, Lubaczeuski C, Cui T, Sha W et al. · Proceedings of the National Academy of Sciences of the United States of America · 2023PubMed Verified

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    Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis

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15. 15.
    Probing for peptidic drugs (2-10 kDa) in doping control blood samples

    Thomas A, Thilmany S, Hofmann A, Thevis M · Analytical science advances · 2022PubMed Verified

16. 16.
    Tumorigenic transformation of human prostatic epithelial cell line RWPE-1 by growth hormone-releasing hormone (GHRH)

    Muñoz-Moreno L, Carmena MJ, Prieto JC, Schally AV, Bajo AM · The Prostate · 2022PubMed Verified

17. 17.
    An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS

    Coppieters G, Deventer K, Polet M, Van Eenoo P, Judák P · Journal of pharmaceutical and biomedical analysis · 2022PubMed Verified

18. 18.
    Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity

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    Impact of growth hormone-releasing hormone antagonist on decidual stromal cell growth and apoptosis in vitro†

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    Advances in the detection of growth hormone releasing hormone synthetic analogs

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    Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD

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    Effects of growth hormone-releasing hormone agonistic analog MR-409 on insulin-secreting cells under cyclopiazonic acid-induced endoplasmic reticulum stress

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23. 23.
    Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

    Cen LP, Ng TK, Liang JJ, Xu C, Zhuang X, Liu YF et al. · Proceedings of the National Academy of Sciences of the United States of America · 2021PubMed Verified

24. 24.
    Growth hormone-releasing hormone antagonistic analog MIA-690 stimulates food intake in mice

    Recinella L, Chiavaroli A, Orlando G, Ferrante C, Gesmundo I, Granata R et al. · Peptides · 2021PubMed Verified

25. 25.
    A potentially effective drug for patients with recurrent glioma: sermorelin

    Chang Y, Huang R, Zhai Y, Huang L, Feng Y, Wang D et al. · Annals of translational medicine · 2021PubMed Verified

26. 26.
    Growth hormone-releasing hormone agonists ameliorate chronic kidney disease-induced heart failure with preserved ejection fraction

    Rieger AC, Bagno LL, Salerno A, Florea V, Rodriguez J, Rosado M et al. · Proceedings of the National Academy of Sciences of the United States of America · 2021PubMed Verified

27. 27.
    Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry

    Pont L, Alechaga É, Terrero A, Monfort N, Ventura R · Journal of chromatography. A · 2020PubMed Verified

28. 28.
    GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity

    Barabutis N, Akhter MS, Uddin MA, Kubra KT, Schally AV · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020PubMed Verified

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    A glimpse at growth hormone-releasing hormone cosmos

    Barabutis N · Clinical and experimental pharmacology & physiology · 2020PubMed Verified

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    Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males

    Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J et al. · Translational andrology and urology · 2020ReviewPubMed Verified

31. 31.
    Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target

    Xiong X, Ke X, Wang L, Yao Z, Guo Y, Zhang X et al. · Proceedings of the National Academy of Sciences of the United States of America · 2020PubMed Verified

32. 32.
    Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation

    Liang WC, Ren JL, Yu QX, Li J, Ng TK, Chu WK et al. · Proceedings of the National Academy of Sciences of the United States of America · 2020PubMed Verified

33. 33.
    Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice

    Recinella L, Chiavaroli A, Orlando G, Ferrante C, Marconi GD, Gesmundo I et al. · Scientific reports · 2020PubMed Verified

34. 34.
    Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

    Belavgeni A, Bornstein SR, von Mässenhausen A, Tonnus W, Stumpf J, Meyer C et al. · Proceedings of the National Academy of Sciences of the United States of America · 2019PubMed Verified

35. 35.
    Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin

    Zhang C, Cai R, Lazerson A, Delcroix G, Wangpaichitr M, Mirsaeidi M et al. · Lung · 2019PubMed Verified

36. 36.
    Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH

    Schally AV, Wang H, He J, Cai R, Sha W, Popovics P et al. · Proceedings of the National Academy of Sciences of the United States of America · 2018PubMed Verified

37. 37.
    Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone-Releasing Hormone Receptors

    Qin YJ, Chu WK, Huang L, Ng CHY, Chan TCY, Cao D et al. · Investigative ophthalmology & visual science · 2018PubMed Verified

38. 38.
    Growth hormone-releasing hormone receptor antagonists modify molecular machinery in the progression of prostate cancer

    Muñoz-Moreno L, Schally AV, Prieto JC, Carmena MJ, Bajo AM · The Prostate · 2018PubMed Verified

39. 39.
    A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone

    Jimenez JJ, DelCanto GM, Popovics P, Perez A, Vila Granda A, Vidaurre I et al. · British journal of haematology · 2018PubMed Verified

40. 40.
    Inhibition of experimental small-cell and non-small-cell lung cancers by novel antagonists of growth hormone-releasing hormone

    Wang H, Zhang X, Vidaurre I, Cai R, Sha W, Schally AV · International journal of cancer · 2018PubMed Verified

41. 41.
    Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

    Thounaojam MC, Powell FL, Patel S, Gutsaeva DR, Tawfik A, Smith SB et al. · Proceedings of the National Academy of Sciences of the United States of America · 2017PubMed Verified

42. 42.
    Re: Antagonists of Growth Hormone-Releasing Hormone Inhibit Proliferation Induced by Inflammation in Prostatic Epithelial Cells

    Atala A · The Journal of urology · 2017PubMed Verified

43. 43.
    Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels

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44. 44.
    Effects of an Antagonistic Analog of Growth Hormone-Releasing Hormone on Endometriosis in a Mouse Model and In Vitro

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45. 45.
    Growth hormone-releasing hormone antagonist inhibits the invasiveness of human endometrial cancer cells by down-regulating twist and N-cadherin expression

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46. 46.
    Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signaling

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    Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells

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48. 48.
    Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing by stimulating the proliferation and survival of human dermal fibroblasts through ERK and AKT pathways

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49. 49.
    Anti-proliferative and pro-apoptotic effects of GHRH antagonists in prostate cancer

    Muñoz-Moreno L, Arenas MI, Carmena MJ, Schally AV, Sánchez-Chapado M, Prieto JC et al. · Oncotarget · 2016PubMed Verified

50. 50.
    Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line

    Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL et al. · Current molecular medicine · 2016PubMed Verified