Epithalon vs Sermorelin
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & Longevity
EpithalonGrowth Hormone PeptidesAnti-Aging & Longevity
Sermorelin- Summary
- Epithalon is a synthetic tetrapeptide developed from the pineal gland extract Epithalamin by Russian scientist Dr. Vladimir Khavinson. It is one of the most researched longevity peptides, known for activating telomerase and extending telomere length — the molecular hallmarks of cellular aging.
- Sermorelin is a bioidentical synthetic peptide comprising the first 29 amino acids of naturally occurring GHRH. It is FDA-approved for diagnostic use and widely prescribed off-label for anti-aging, stimulating growth hormone production in a natural pulsatile pattern that mimics the body's own rhythm.
- Half-Life
- 2–4 hours
- 10–20 minutes
- Admin Route
- SubQ, Sublingual
- SubQ
- Research
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- Typical Dose
- 5–10 mg total per cycle
- 200–500 mcg
- Frequency
- 0.5–1 mg daily
- 5–7 days per week
- Key Benefits
- Activates telomerase enzyme, extending telomere length
- May slow cellular and biological aging
- Regulates melatonin production and circadian rhythms
- Improves sleep quality
- Powerful antioxidant properties
- May reduce incidence of age-related diseases
- Supports immune system function
- Studied for cancer prevention properties in animal models
- Increases energy and vitality
- Improves body composition (more muscle, less fat)
- Enhances skin thickness and elasticity
- Strengthens immune system
- Improves sleep quality and REM sleep
- Supports bone density
- Enhances mental clarity and focus
- Safer than exogenous HGH — respects natural feedback loops
- FDA-approved for GH diagnostic use
- Side Effects
- Injection site irritation (mild)
- Temporary sleep changes during cycle (usually improves)
- Rare: fatigue
- Injection site irritation
- Flushing
- Headache
- Dizziness
- +2 more
- Stacks With
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