Epithalon vs Glutathione
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & Longevity
EpithalonAnti-Aging & LongevityImmune Support
Glutathione- Summary
- Epithalon is a synthetic tetrapeptide developed from the pineal gland extract Epithalamin by Russian scientist Dr. Vladimir Khavinson. It is one of the most researched longevity peptides, known for activating telomerase and extending telomere length — the molecular hallmarks of cellular aging.
- Glutathione is the body's master endogenous antioxidant tripeptide, composed of glutamate, cysteine, and glycine. It neutralizes reactive oxygen species, supports detoxification in the liver, recycles other antioxidants (vitamins C and E), and plays a central role in immune function, DNA repair, and cellular redox balance.
- Half-Life
- 2–4 hours
- Minutes to hours depending on route; IV half-life approximately 10-30 minutes
- Admin Route
- SubQ, Sublingual
- Oral (liposomal preferred), Sublingual, Intravenous, Nebulized/inhaled, Topical
- Research
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- Typical Dose
- 5–10 mg total per cycle
- 250-1000 mg per day
- Frequency
- 0.5–1 mg daily
- Once or twice daily
- Key Benefits
- Activates telomerase enzyme, extending telomere length
- May slow cellular and biological aging
- Regulates melatonin production and circadian rhythms
- Improves sleep quality
- Powerful antioxidant properties
- May reduce incidence of age-related diseases
- Supports immune system function
- Studied for cancer prevention properties in animal models
- Primary endogenous antioxidant and free radical scavenger
- Supports hepatic detoxification of xenobiotics and heavy metals
- Recycles vitamins C and E to maintain antioxidant network
- Modulates immune function and T-cell activity
- Skin brightening via inhibition of tyrosinase (IV/topical routes)
- Neuroprotective in oxidative stress-related conditions
- Mitochondrial protection and energy metabolism support
- Side Effects
- Injection site irritation (mild)
- Temporary sleep changes during cycle (usually improves)
- Rare: fatigue
- Oral bioavailability is limited (largely hydrolyzed in gut); liposomal or sublingual forms preferred
- IV administration: rare allergic reactions, vein irritation
- High-dose supplementation may cause zinc depletion over time
- Inhaled glutathione may trigger bronchoconstriction in asthmatics
- Stacks With
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