Decapeptide-12 vs Palmitoyl Tetrapeptide-7
Side-by-side comparison of key properties, dosing, and research.
Skin & Cosmetic
Decapeptide-12Skin & Cosmetic
Palmitoyl Tetrapeptide-7- Summary
- Decapeptide-12 is a synthetic 10-amino acid peptide developed for skin brightening and depigmentation. It selectively inhibits tyrosinase activity and downstream melanogenesis pathways, reducing hyperpigmentation, dark spots, and uneven skin tone without the irritation associated with hydroquinone.
- Palmitoyl Tetrapeptide-7 (Rigin) is a cosmetic peptide consisting of palmitic acid linked to the tetrapeptide sequence GQPR (Gly-Gln-Pro-Arg). It was designed to mimic the biological activity of the IgG immunoglobulin C-terminus, which downregulates the production of interleukin-6 (IL-6), a key driver of skin aging and inflammation.
- Half-Life
- Not applicable (topical)
- Topical penetration-dependent; effects last hours to days
- Admin Route
- Topical
- Topical
- Research
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- Typical Dose
- 5 ppm (0.0005%) concentration
- 2-5 ppm concentration in formulation
- Frequency
- Twice daily (AM and PM)
- Twice daily
- Key Benefits
- Reduces hyperpigmentation and dark spots
- Evens skin tone and improves radiance
- Inhibits post-inflammatory hyperpigmentation
- Well-tolerated alternative to hydroquinone
- Effective for melasma and age spots
- Non-cytotoxic to melanocytes
- Reduces IL-6 inflammatory cytokine in skin
- Prevents 'inflammaging' of the skin
- Inhibits MMP collagen-degrading enzymes
- Synergistic with Matrixyl for anti-aging
- Clinically tested for wrinkle and skin texture improvement
- Well-tolerated topically
- Side Effects
- Generally very well-tolerated
- Rare mild irritation or sensitivity in some skin types
- Results may take several weeks to become visible
- Contact sensitization (rare)
- Well-tolerated at standard concentrations
- Stacks With
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