Vesugen
Also known as: Lys-Glu-Asp, Khavinson vascular peptide, Vascular bioregulator
Vesugen is a tripeptide bioregulator (Lys-Glu-Asp) developed by Professor Vladimir Khavinson, tissue-specific for blood vessels and the vascular endothelium. It supports endothelial cell function, promotes vascular wall integrity, and is studied for atherosclerosis prevention, vascular aging, and cardiovascular health maintenance. It is one of the more broadly applicable Khavinson bioregulators given the ubiquity of vascular tissue.
Half-Life
Short (minutes); sustained gene-regulatory effects
Route
SubQ, Oral
Category
Anti-Aging & Longevity
Studies
15 references
Key Benefits
- Supports vascular endothelial cell function and integrity
- May reduce endothelial inflammation and dysfunction
- Anti-aging effects on blood vessel walls
- Potential benefits in early atherosclerosis and vascular aging
- Supports nitric oxide-mediated vascular tone
- Reduces endothelial apoptosis from oxidative stress
- Complementary to Cardiogen and Epithalon in cardiovascular longevity protocols
Mechanism of Action
Vesugen's tripeptide Lys-Glu-Asp modulates gene expression in vascular endothelial and smooth muscle cells. By interacting with chromatin, it normalizes protein synthesis of endothelial function markers, reduces endothelial apoptosis, and may downregulate pro-inflammatory and pro-atherogenic gene expression. It supports nitric oxide synthase activity, vascular tone regulation, and integrity of the extracellular matrix in vessel walls.
Dosing Protocols
Standard Khavinson Protocol
- Dose
- 10 mg per day
- Frequency
- Daily for 10–30 days
- Timing
- Subcutaneous injection or oral (enteric-coated)
- Cycle
- 10–30 day course, repeated 2–4x per year
Often combined with Cardiogen and Epithalon in cardiovascular anti-aging protocols. Research use only.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally well tolerated
- Mild injection site reactions
- No significant vascular adverse events reported at standard doses
Contraindications
Not FDA approved. Not a substitute for statins, antihypertensives, or standard cardiovascular medications. Medical oversight required for diagnosed vascular disease.
Storage
Store at 2–8°C. Protect from moisture and light.
Clinical Research
- 1.Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes
Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D et al. · International journal of molecular sciences · 2024PubMed Verified
- 2.Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease
Khavinson VK, Lin'kova NS, Umnov RS · Bulletin of experimental biology and medicine · 2021ReviewPubMed Verified
- 3.Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides
Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B · Molecular biology reports · 2020PubMed Verified
- 4.Effect of short peptides on neuronal differentiation of stem cells
Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N et al. · International journal of immunopathology and pharmacology · 2019PubMed Verified
- 5.Spontaneous death of rat chloroleukaemia cells induced by an endogenous growth inhibitor
Rytömaa T, Grip-Rytömaa K · Cell proliferation · 2018PubMed Verified
- 6.Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro
Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM et al. · Bulletin of experimental biology and medicine · 2016PubMed Verified
- 7.Molecular aspects of anti-atherosclerotic effects of short peptides
Khavinson VKh, Lin'kova NS, Evlashkina EV, Durnova AO, Kozlov KL, Gutop OE · Bulletin of experimental biology and medicine · 2014PubMed Verified
- 8.Short peptides stimulate serotonin expression in cells of brain cortex
Khavinson VKh, Lin'kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO · Bulletin of experimental biology and medicine · 2014PubMed Verified
- 9.Synthesis and activity of a cyclo-heptapeptide containing Lys-Gly-Asp-sequence as a novel anti-platelet agent
Jing J · Bioorganicheskaia khimiia · 2013PubMed Verified
- 10.Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells
Chalisova NI, Lopatina NG, Kamishev NG, Linkova NS, Koncevaya EA, Dudkov AV et al. · Bulletin of experimental biology and medicine · 2012PubMed Verified
- 11.Peptides tissue-specifically stimulate cell differentiation during their aging
Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM · Bulletin of experimental biology and medicine · 2012PubMed Verified
- 12.Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats
Voicekhovskaya MA, Chalisova NI, Kontsevaya EA, Ryzhak GA · Bulletin of experimental biology and medicine · 2012PubMed Verified
- 13.Effect of short peptides on expression of signaling molecules in organotypic pineal cell culture
Khavinson VKh, Linkova NS, Chalisova NI, Dudkov AV, Koncevaya EA · Bulletin of experimental biology and medicine · 2011PubMed Verified
- 14.Peptidegic stimulation of differentiation of pineal immune cells
Linkova NS, Khavinson VKh, Chalisova NI, Katanugina AS, Koncevaya EA · Bulletin of experimental biology and medicine · 2011PubMed Verified
- 15.Protective effect of tripeptide in the presence of cyclophosphamide on the growth of cultured lymphoid tissue from rats of different age
Chalisova NI, Lesnyak VV, Oganezova EV, Rizhak GA · Bulletin of experimental biology and medicine · 2008PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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