Syn-Coll

Key Benefits#

• Directly activates TGF-beta for potent collagen synthesis stimulation
• Increases dermal thickness and firmness
• Reduces depth of wrinkles and fine lines
• Improves skin elasticity
• Clinically validated in collagen induction studies
• Complementary to retinoids or vitamin C

Mechanism of Action#

Syn-Coll mimics the sequence of thrombospondin-1 that activates latent TGF-beta. Once activated, TGF-beta binds to fibroblast receptors to upregulate COL1A1, COL1A2, and COL3A1 transcription. The palmitoyl tail facilitates dermal penetration for TGF-beta activation at the fibroblast level.

Dosing Protocols#

Side Effects#

• Generally well-tolerated
• Rare mild irritation at high concentrations
• Possible sensitivity in individuals with inflammatory skin conditions

Contraindications#

Known peptide sensitivityActive inflammatory skin conditionsCaution in pregnancy

Storage#

Store in a cool, dark location in sealed, opaque container. Sensitive to heat and oxidation. Refrigerate after opening.

1. 1.
   Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects

   Chen W, Xiang N, Huang J, Xu H, Wang Z, Ruan B et al. · Colloids and surfaces. B, Biointerfaces · 2025PubMed Verified

2. 2.
   Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

   Shariati Pour SR, Oddis S, Barbalinardo M, Ravarino P, Cavallini M, Fiori J et al. · Molecules (Basel, Switzerland) · 2023PubMed Verified

3. 3.
   Usage of Synthetic Peptides in Cosmetics for Sensitive Skin

   Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF · Pharmaceuticals (Basel, Switzerland) · 2021ReviewPubMed Verified

4. 4.
   Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study

   Avcil M, Akman G, Klokkers J, Jeong D, Çelik A · Journal of cosmetic dermatology · 2020Clinical TrialPubMed Verified