Syn-Ake
Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate, synthetic viper venom peptide, snake venom mimic peptide
Syn-Ake is a synthetic tripeptide that mimics waglerin-1, a peptide found in the venom of the Temple viper (Tropidolaemus wagleri). It acts as a reversible antagonist of muscular nicotinic acetylcholine receptors, temporarily reducing facial muscle contraction and smoothing dynamic wrinkles. Often called a 'synthetic Botox' in cosmetic marketing.
Half-Life
Not applicable (topical; effect duration hours)
Route
Topical
Category
Skin & Cosmetic, Anti-Aging & Longevity
Studies
2 references
Key Benefits
- Reduces depth of dynamic wrinkles and expression lines
- Reversible muscle-relaxing effect on facial muscles
- Smooths forehead lines, crow's feet, and frown lines
- Non-invasive alternative to injectable neurotoxins
- Rapid onset relative to collagen-stimulating peptides
- Well-studied in in vitro and clinical cosmetic trials
Mechanism of Action
Syn-Ake competitively blocks the muscular nicotinic acetylcholine receptor (mAChR) at the neuromuscular junction, reducing acetylcholine-mediated muscle depolarization. This decreases the contractile amplitude of facial expression muscles, particularly in the forehead and periorbital region. The mechanism is analogous to curare-type muscle relaxants but is reversible, concentration-dependent, and non-systemic at topical doses.
Dosing Protocols
Anti-Wrinkle (Standard)
- Dose
- 0.01–0.1% (4–8 mg/g in clinical studies)
- Frequency
- Twice daily
- Timing
- AM and PM, applied to target expression areas
- Cycle
- 4–8 weeks for initial assessment; ongoing use
Clinical studies at 4 mg/g showed significant wrinkle depth reduction after 4 weeks. Often combined with Argireline or Pentapeptide-18 for multi-mechanism neurotoxin-like activity. Apply 30 minutes before makeup.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally very well-tolerated topically
- Rare skin sensitivity or contact dermatitis
- Theoretical neuromuscular effects at systemic doses (not relevant topically)
Contraindications
Known sensitivity to synthetic peptides or acetate saltsCaution with myasthenia gravis or neuromuscular disorders (theoretical concern)Pregnancy: insufficient safety data
Storage
Store at room temperature, away from direct sunlight and heat. Stable in aqueous formulations at pH 4–7. Avoid temperature extremes and prolonged air exposure.
Clinical Research
- 1.Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests
Gok B, Budama-Kilinc Y, Kecel-Gunduz S · Journal of biomolecular structure & dynamics · 2024PubMed Verified
- 2.The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies
Zhu M, He X, Zhu Z, Lynch S, Wang H, Zhou X et al. · International journal of cosmetic science · 2026PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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