SNAP-8
Also known as: Acetyl Octapeptide-3, Leuphasyl, Octapeptide-3
SNAP-8 is a synthetic octapeptide cosmetic ingredient that reduces the depth of expression lines and wrinkles by competitively inhibiting the SNARE complex involved in acetylcholine release at neuromuscular junctions, providing a topical 'Botox-like' effect.
Half-Life
N/A — topical application; local effect duration depends on formulation
Route
Topical
Category
Skin & Cosmetic
Studies
2 references
Key Benefits
- Reduces depth of dynamic expression wrinkles
- Smooths forehead lines, crow's feet, glabellar lines
- Non-invasive topical Botox alternative
- Can be incorporated into serums, creams, eye contour products
- Reduces muscle contraction without paralysis
- Improves skin texture and firmness over time
- Complements other anti-aging peptides (Argireline, Matrixyl)
Mechanism of Action
SNAP-8 is an 8-amino acid analog of the N-terminal portion of SNAP-25 (synaptosomal-associated protein 25), a component of the SNARE complex. SNAP-8 competes with native SNAP-25 for a position in the SNARE complex assembly, preventing acetylcholine vesicle docking and release at neuromuscular junctions. Reduced acetylcholine release means reduced muscle contraction intensity, which over time decreases the formation and depth of dynamic wrinkles (expression lines around eyes, forehead, mouth). Unlike Botox, SNAP-8 does not cause muscle paralysis.
Dosing Protocols
Anti-Wrinkle Serum Protocol
- Dose
- 3–10% concentration in formulation
- Frequency
- 1–2x daily
- Timing
- Morning and/or evening after cleansing
- Cycle
- Ongoing; visible results typically in 28–56 days
Most effective on expression lines (dynamic wrinkles); use in combination with Argireline for enhanced effect
Eye Contour Protocol
- Dose
- 5–8% concentration
- Frequency
- Twice daily
- Timing
- AM and PM on clean skin around eyes
- Cycle
- Ongoing
Apply 2–3 drops around eye area; do not exceed 10% concentration
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally excellent tolerability
- Rare: mild redness in sensitive individuals
- Not suitable for injection (topical use only)
Contraindications
External use only. Avoid contact with eyes. Not for injection. Consult dermatologist if using alongside prescription retinoids or active treatments.
Storage
Store lyophilized ingredient at -20°C. Finished cosmetic formulations: cool, dry place per product instructions. Typically stable for 24 months.
Featured In Stacks
Advanced Cosmetic Anti-Aging Topical Stack
Comprehensive topical peptide system targeting expression lines, skin laxity, collagen degradation, and oxidative damage. Suitable for daily facial and neck application.
Advanced Skin Rejuvenation & Anti-Aging Cosmetic Protocol
Comprehensive cosmetic peptide protocol targeting collagen synthesis, wrinkle reduction, skin elasticity, hyperpigmentation, and epidermal regeneration for clinically significant anti-aging skin improvement.
Anti-Aging Skin & Cosmetic Protocol
A comprehensive skin rejuvenation protocol combining injectable and topical peptides to stimulate collagen synthesis, reverse expression lines, and accelerate skin regeneration — attacking aging from both systemic and topical angles simultaneously.
Comprehensive Anti-Aging Skincare Stack
A complete multi-peptide topical skincare system targeting all major aging mechanisms: collagen loss, expression lines, photo-aging, inflammation, and loss of skin firmness for comprehensive facial rejuvenation.
Clinical Research
- 1.Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities
Shin JY, Han D, Yoon KY, Jeong DH, Park YI · Annals of dermatology · 2024PubMed Verified
- 2.Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study
Avcil M, Akman G, Klokkers J, Jeong D, Çelik A · Journal of cosmetic dermatology · 2020Clinical TrialPubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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