Palmitoyl Dipeptide-6

Key Benefits#

• Increases skin firmness and density
• Stimulates fibronectin and collagen IV production
• Strengthens the dermal-epidermal junction
• Reduces skin sagging in mature skin
• Improves skin texture and smoothness
• Supports extracellular matrix integrity

Mechanism of Action#

Palmitoyl Dipeptide-6 mimics the KTTKS signal sequence found in fibronectin and signals dermal fibroblasts via integrin receptors. It upregulates fibronectin, collagen IV, and lumican expression, reinforcing the dermal-epidermal junction and the structural scaffold of the dermis. The palmitoyl chain enables effective penetration through the stratum corneum for sustained intradermal activity.

Dosing Protocols#

Side Effects#

• Generally well-tolerated
• Rare mild skin irritation in sensitive individuals
• No known systemic effects at cosmetic concentrations

Contraindications#

Known dipeptide or palmitoyl ester sensitivityNot studied in pregnancy at high concentrations

Storage#

Store at room temperature in a sealed container away from direct sunlight. Stable in pH 4–8 formulations. Avoid freezing.

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