Pal-GHK
Also known as: Palmitoyl GHK, Palmitoyl Tripeptide-1, Pal-GHK (non-copper)
Pal-GHK is the palmitoylated form of the GHK tripeptide without a copper ion. By conjugating palmitic acid to glycine-histidine-lysine, skin penetration is substantially enhanced, enabling deeper dermal collagen stimulation. It is commonly paired with Pal-GHK-Cu or GHK-Cu in anti-aging formulations.
Half-Life
Extended (lipid depot in stratum corneum)
Route
Topical
Category
Skin & Cosmetic, Anti-Aging & Longevity
Studies
5 references
Key Benefits
- Stimulates collagen I and III synthesis in dermis
- Reduces the appearance of fine lines and wrinkles
- Improves skin elasticity and firmness
- Inhibits collagenase (MMP-1) to preserve existing collagen
- Enhances wound healing and skin repair
- Well-tolerated in anti-aging serums and creams
Mechanism of Action
Pal-GHK enhances dermal penetration via the palmitate lipid tail and signals fibroblasts to upregulate collagen I, III, elastin, and glycosaminoglycan synthesis. It activates TGF-β and insulin growth factor receptor pathways, increases fibronectin production, and inhibits MMP-1 (collagenase), reducing collagen degradation. Without copper, the mechanism is growth factor signaling-dominant rather than metalloenzyme-mediated.
Dosing Protocols
Anti-Aging (Standard)
- Dose
- 0.005–0.1% in formulation
- Frequency
- Once or twice daily
- Timing
- PM primarily; AM with SPF acceptable
- Cycle
- 12–24 weeks, ongoing
Often formulated alongside Pal-GHK-Cu and Matrixyl (Pal-KTTKS) for a comprehensive anti-aging peptide complex. Avoid strong acid exfoliants in the same step to preserve peptide integrity.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally very well-tolerated
- Rare skin irritation at very high concentrations
- Possible formulation-dependent comedogenicity
Contraindications
Known sensitivity to palmitoyl esters or GHK peptideActive skin infections
Storage
Store in a cool, dark location. Sensitive to oxidation and hydrolysis; sealed airless pump containers preferred. Refrigerate after opening for extended shelf life.
Clinical Research
- 1.Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR · BioImpacts : BI · 2025ReviewPubMed Verified
- 2.Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines
Hong M, Gui Y, Xu J, Zhao X, Jiang C, Zhao J et al. · Biochemical and biophysical research communications · 2025PubMed Verified
- 3.Clinical assessment of a combination lip treatment to restore moisturization and fullness
Trookman NS, Rizer RL, Ford R, Mehta R, Gotz V · The Journal of clinical and aesthetic dermatology · 2009PubMed Verified
- 4.Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics
Chirita RI, Chaimbault P, Archambault JC, Robert I, Elfakir C · Analytica chimica acta · 2009PubMed Verified
- 5.Self-assembly of palmitoyl lipopeptides used in skin care products
Castelletto V, Hamley IW, Whitehouse C, Matts PJ, Osborne R, Baker ES · Langmuir : the ACS journal of surfaces and colloids · 2013PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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