Pal-AHK
Also known as: Palmitoyl AHK, Palmitoyl Alanine-Histidine-Lysine, Copper Peptide Palmitoyl
Pal-AHK is the palmitoylated form of the AHK-Cu copper tripeptide, created by attaching a palmitic acid chain to enhance skin penetration and lipid bilayer affinity. The palmitoyl modification significantly improves dermal bioavailability compared to unmodified AHK, making it particularly effective in anti-aging and hair growth formulations.
Half-Life
Extended (lipid depot effect in stratum corneum)
Route
Topical
Category
Skin & Cosmetic, Anti-Aging & Longevity
Key Benefits
- Enhanced skin penetration vs. unmodified AHK-Cu
- Stimulates dermal collagen and elastin production
- Promotes hair follicle anagen phase
- Antioxidant and wound healing activity
- Firming and plumping effect on aging skin
- Improved bioavailability via lipid bilayer incorporation
Mechanism of Action
The palmitic acid chain anchors Pal-AHK into the stratum corneum lipid bilayer, enabling sustained release of the AHK peptide into the dermis. Once in the dermis, the AHK tripeptide chelates copper and activates metalloenzymes involved in collagen cross-linking, elastin synthesis, and follicular growth factor signaling. The improved penetration leads to more sustained VEGF stimulation and TGF-β pathway activation compared to unmodified AHK-Cu.
Dosing Protocols
Anti-Aging Skin (Standard)
- Dose
- 0.01–0.05% in formulation
- Frequency
- Once or twice daily
- Timing
- PM preferred; AM with SPF
- Cycle
- 12–24 weeks
Often combined with Pal-GHK for a comprehensive palmitoyl copper peptide complex. Avoid use with high concentrations of AHAs or strong retinoids in the same step.
Hair Growth (Scalp Serum)
- Dose
- 0.02–0.1% in scalp serum
- Frequency
- Once daily
- Timing
- Applied to scalp, leave-in
- Cycle
- 16–24 weeks
Can be combined with AHK-Cu for dual copper peptide hair support. Massage gently into scalp to enhance absorption.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally well-tolerated
- Mild irritation at high concentrations in sensitive skin
- Possible comedogenicity at very high palmitate concentrations (formulation-dependent)
Contraindications
Known copper or palmitoyl ester sensitivityActive skin infections
Storage
Store in a cool, dark location. Palmitoyl peptides can be sensitive to oxidation and hydrolysis; prefer sealed, opaque containers. Refrigerate if storing for extended periods.
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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