P21

Key Benefits#

• Promotes hippocampal neurogenesis
• Enhances spatial memory and learning
• Increases BDNF expression
• Reduces amyloid-beta plaque formation (animal models)
• Anti-tau pathology potential
• Cognitive enhancement without stimulant effects
• Potential therapeutic for Alzheimer's and cognitive aging

Mechanism of Action#

P21 is a 5-amino acid active region of CNTF that avoids the JAK/STAT pathway (which causes weight loss and side effects in full CNTF) while retaining neurogenic activity. It activates CNTF receptor alpha (CNTFRα) to promote adult hippocampal neurogenesis. P21 also increases BDNF expression and has been shown in animal models to reduce amyloid-beta plaques and tau pathology. It promotes long-term potentiation and spatial memory formation in the hippocampus.

Dosing Protocols#

Side Effects#

• Generally well tolerated in animal studies
• Limited human clinical data
• Injection site reactions
• Potential mild fatigue at initiation

Contraindications#

Insufficient human safety data — research peptide status. Use with caution alongside neuropsychiatric medications. Not for use in active cancer treatment.

Storage#

Store lyophilized at -20°C. Reconstituted at 4°C, use within 30 days. Protect from light.

Featured In Stacks#

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