Ovagen
Also known as: Glu-Asp-Leu, Khavinson liver bioregulator, Hepatic tripeptide
Ovagen is a tripeptide bioregulator (Glu-Asp-Leu) developed by Professor Vladimir Khavinson, primarily targeting liver tissue. It supports hepatocyte function, liver cell regeneration, and protection against hepatic aging and disease. Ovagen is used in protocols for chronic liver disease, hepatoprotection, and metabolic liver conditions including fatty liver disease.
Half-Life
Short (minutes); sustained gene-regulatory effects
Route
SubQ, Oral
Category
Anti-Aging & Longevity
Studies
34 references
Key Benefits
- Hepatoprotective effects against toxic, viral, and metabolic liver damage
- Promotes hepatocyte regeneration and liver tissue repair
- May reduce liver fibrosis progression
- Supports liver metabolic function and detoxification capacity
- Anti-aging effects on hepatic tissue
- Useful in NAFLD/MASH supportive protocols
- Compatible with NAD+, glutathione, and BPC-157 in liver health stacks
Mechanism of Action
Ovagen's tripeptide sequence Glu-Asp-Leu modulates gene expression in hepatocytes, normalizing protein synthesis essential for liver metabolic function. It reduces hepatocyte apoptosis, supports regenerative capacity of the liver, and may downregulate pro-inflammatory pathways contributing to fibrosis. The peptide acts as a short epigenetic regulator, interacting with chromatin to restore youthful patterns of gene expression in aged or damaged liver tissue.
Dosing Protocols
Standard Khavinson Protocol
- Dose
- 10 mg per day
- Frequency
- Daily for 10–30 days
- Timing
- Subcutaneous injection or oral (enteric-coated)
- Cycle
- 10–30 day course, repeated 2–4x per year
Often combined with Livagen and NAD+ in liver health protocols. Research use only.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally well tolerated
- Mild injection site reactions
- No clinically significant hepatotoxicity reported
Contraindications
Not FDA approved. Not a substitute for antiviral hepatitis therapy, statins, or standard hepatology treatments. Medical oversight recommended for active liver disease.
Storage
Store at 2–8°C. Protect from moisture and light.
Clinical Research
- 1.A Novel Method to Sterilize Isolators for the Housing of Germ-Free Birds and Production of Germ-Free Eggs
Murphy M, Jones R, Dos Santos A, Adeyemi M, Caulfield C · Applied biosafety : journal of the American Biological Safety Association · 2025PubMed Verified
- 2.Towards better process management in wastewater treatment plants: Process analytics based on SHAP values for tree-based machine learning methods
Wang D, Thunéll S, Lindberg U, Jiang L, Trygg J, Tysklind M · Journal of environmental management · 2022PubMed Verified
- 3.Pulmonary Recruitment Maneuver Reduces Shoulder Pain and Nausea After Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Kihlstedt Pasquier E, Andersson E · World journal of surgery · 2021RCTPubMed Verified
- 4.A machine learning framework to improve effluent quality control in wastewater treatment plants
Wang D, Thunéll S, Lindberg U, Jiang L, Trygg J, Tysklind M et al. · The Science of the total environment · 2021PubMed Verified
- 5.Does comprehensive geriatric assessment (CGA) in an outpatient care setting affect the causes of death and the quality of palliative care? A subanalysis of the age-FIT study
Dahlqvist J, Ekdahl A, Friedrichsen M · European geriatric medicine · 2019PubMed Verified
- 6.Prepared for Mission? A Survey of Medical Personnel Training Needs Within the International Committee of the Red Cross
Haverkamp FJC, Veen H, Hoencamp R, Muhrbeck M, von Schreeb J, Wladis A et al. · World journal of surgery · 2018PubMed Verified
- 7.Deaths caused by injury among people of working age (18-64) are decreasing, while those among older people (64+) are increasing
Bäckström D, Larsen R, Steinvall I, Fredrikson M, Gedeborg R, Sjöberg F · European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018PubMed Verified
- 8.Picture book support for preparing children ahead of and during day surgery
Nilsson E, Svensson G, Frisman GH · Nursing children and young people · 2016PubMed Verified
- 9.Diastolic orthostatic hypertension and cardiovascular prognosis in type 2 diabetes: a prospective cohort study
Wijkman M, Länne T, Östgren CJ, Nystrom FH · Cardiovascular diabetology · 2016PubMed Verified
- 10.Validation-verification of a highly effective, practical human testicular tissue in vitro culture-cryopreservation procedure aimed to optimize pre-freeze and post-thaw motility
Schiewe MC, Rothman C, Spitz A, Werthman PE, Zeitlin SI, Anderson RE · Journal of assisted reproduction and genetics · 2016PubMed Verified
- 11.Validation of microSecure vitrification (μS-VTF) for the effective cryopreservation of human embryos and oocytes
Schiewe MC, Zozula S, Anderson RE, Fahy GM · Cryobiology · 2015PubMed Verified
- 12.Approval summary: letrozole (Femara® tablets) for adjuvant and extended adjuvant postmenopausal breast cancer treatment: conversion of accelerated to full approval
Cohen MH, Johnson JR, Justice R, Pazdur R · The oncologist · 2011ReviewPubMed Verified
- 13.Effects of low-dose follicle-stimulating hormone administration on follicular dynamics and preovulatory follicle characteristics in dairy cows during the summer
Friedman E, Glick G, Lavon Y, Roth Z · Domestic animal endocrinology · 2010PubMed Verified
- 14.Transvaginal follicular aspiration and embryo development in superstimulated early postpartum beef cows and subsequent fertility after artificial insemination
Aller JF, Mucci NC, Kaiser GG, Ríos G, Callejas SS, Alberio RH · Animal reproduction science · 2010RCTPubMed Verified
- 15.Effect of porcine and ovine FSH on nuclear maturation of pig oocytes in vitro
Samartzi F, Tsakmakidis I, Theodosiadou E, Vainas E · Reproduction in domestic animals = Zuchthygiene · 2008PubMed Verified
- 16.Effects of ovum pick-up frequency and FSH stimulation: a retrospective study on seven years of beef cattle in vitro embryo production
De Roover R, Feugang JM, Bols PE, Genicot G, Hanzen Ch · Reproduction in domestic animals = Zuchthygiene · 2008PubMed Verified
- 17.The effects of the prostaglandin E analogue Misoprostol and follicle-stimulating hormone on cervical penetrability in ewes during the peri-ovulatory period
Leethongdee S, Khalid M, Bhatti A, Ponglowhapan S, Kershaw CM, Scaramuzzi RJ · Theriogenology · 2007PubMed Verified
- 18.Effects of progestagens on follicular growth and oocyte developmental competence in FSH-treated ewes
Berlinguer F, Gonzalez-Bulnes A, Succu S, Leoni G, Mossa F, Bebbere D et al. · Domestic animal endocrinology · 2007PubMed Verified
- 19.The effect of melatonin implants during the seasonal anestrus on embryo production after superovulation in aged high-prolificacy Rasa Aragonesa ewes
Forcada F, Abecia JA, Cebrián-Pérez JA, Muiño-Blanco T, Valares JA, Palacín I et al. · Theriogenology · 2006PubMed Verified
- 20.Plasma inhibin A determination at start superovulatory FSH treatments is predictive for embryo outcome in goats
Gonzalez-Bulnes A, Garcia-Garcia RM, Carrizosa JA, Urrutia B, Souza CJ, Cocero MJ et al. · Domestic animal endocrinology · 2004PubMed Verified
- 21.Procedure for successful interspecific embryo transfer from mouflon (Ovis gmelini musimon) to Spanish Merino sheep (Ovis aries)
Santiago-Moreno J, González-Bulnes A, Gómez-Brunet A, Cocero MJ, del Campo A, García-García R et al. · Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2001PubMed Verified
- 22.Influence of maternal environment on the number of transferable embryos obtained in response to superovulatory FSH treatments in ewes
González-Bulnes A, García-García RM, Castellanos V, Santiago-Moreno J, Ariznavarreta C, Domínguez V et al. · Reproduction, nutrition, development · 2003PubMed Verified
- 23.Reproductive season affects inhibitory effects from large follicles on the response to superovulatory FSH treatments in ewes
Gonzalez-Bulnes A, Garcia-Garcia RM, Santiago-Moreno J, Dominguez V, Lopez-Sebastian A, Cocero MJ · Theriogenology · 2003PubMed Verified
- 24.Patterns of follicular growth in superovulated sheep and influence on endocrine and ovarian response
Gonzalez-Bulnes A, Garcia-Garcia RM, Souza CJ, Santiago-Moreno J, Lopez-Sebastian A, Cocero MJ et al. · Reproduction in domestic animals = Zuchthygiene · 2002PubMed Verified
- 25.Effect of follicular status on superovulatory response in ewes is influenced by presence of corpus luteum at first FSH dose
Gonzalez-Bulnes A, Garcia-Garcia RM, Santiago-Moreno J, Lopez-Sebastian A, Cocero MJ · Theriogenology · 2002PubMed Verified
- 26.Effects of oestradiol and progesterone on secretion of gonadotrophins and health of first wave follicles during the oestrous cycle of beef heifers
Austin EJ, Mihm M, Evans AC, Ireland JL, Ireland JJ, Roche JF · Reproduction (Cambridge, England) · 2002PubMed Verified
- 27.Effects of FSH commercial preparation and follicular status on follicular growth and superovulatory response in Spanish Merino ewes
Gonzalez-Bulnes A, Santiago-Moreno J, Cocero MJ, Lopez-Sebastian A · Theriogenology · 2000PubMed Verified
- 28.The effect of gonadotrophin releasing hormone and follicle stimulating hormone in conjunction with pregnant mare serum gonadotrophin on the superovulatory response in crossbred sheep in India
Naqvi SM, Gulyani R · Tropical animal health and production · 1998PubMed Verified
- 29.Superovulatory response of dairy cattle (Bos taurus ) in a tropical environment
Kanuya N, Callesen H, Hyttel P, Assey R, Greve T · Theriogenology · 1997PubMed Verified
- 30.Biopotency in vitro and metabolic clearance rates of five pituitary preparations of follicle stimulating hormone
Phillips DJ, Hudson NL, Lun S, Condell LA, McNatty KP · Reproduction, fertility, and development · 1993PubMed Verified
- 31.Use of single or multiple injections of FSH in embryo collection programmes in goats
Batt PA, Killeen ID, Cameron AW · Reproduction, fertility, and development · 1993PubMed Verified
- 32.Luteinizing hormone and follicle stimulating hormone induce premature condensation of chromatin in goat (Capra hircus) oocytes
Kumar J, Osborn JC, Cameron AW · Reproduction, fertility, and development · 1991PubMed Verified
- 33.Oocyte production and ovarian steroid concentrations of immature rats in response to some commercial gonadotrophin preparations
Henderson KM, Weaver A, Wards RL, Ball K, Lun S, Mullin C et al. · Reproduction, fertility, and development · 1990PubMed Verified
- 34.Superovulation and embryo recovery in goats treated with Ovagen and Folltropin
McNatty KP, Hudson NL, Ball K, Mason A, Simmons MH · New Zealand veterinary journal · 1989PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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