Nonapeptide-1
Also known as: Melanostatine-5, MFML peptide, melanogenesis inhibitor peptide
Nonapeptide-1 is a synthetic 9-amino acid peptide that inhibits melanin production by blocking α-MSH (alpha-melanocyte stimulating hormone) receptor binding. Used in cosmetic formulations for skin lightening and evening skin tone, it is particularly effective for UV-induced and hormonal hyperpigmentation.
Half-Life
Not applicable (topical)
Route
Topical
Category
Skin & Cosmetic
Studies
4 references
Key Benefits
- Inhibits UV-induced tanning and hyperpigmentation
- Reduces hormonal melasma
- Evens skin tone at receptor level
- Well-tolerated with minimal irritation
- Complementary to tyrosinase inhibitors for enhanced brightening
- Reduces post-inflammatory hyperpigmentation
Mechanism of Action
Nonapeptide-1 is a competitive antagonist of the MC1R (melanocortin-1 receptor) on melanocytes. By blocking α-MSH binding, it prevents cAMP elevation and the downstream PKA activation that normally drives MITF expression and tyrosinase synthesis. This receptor-level blockade reduces melanogenesis more upstream than tyrosinase inhibitors like Decapeptide-12, providing complementary depigmentation activity.
Dosing Protocols
Skin Brightening (Standard)
- Dose
- 0.05–0.5% concentration in formulation
- Frequency
- Twice daily
- Timing
- AM and PM after cleansing
- Cycle
- 8–16 weeks
Combine with SPF 30+ during daytime use. Can be stacked with Decapeptide-12 or vitamin C for multi-pathway brightening. Consistent daily use required for visible results.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally very well-tolerated
- Rare contact sensitivity in susceptible individuals
- Theoretical risk of excessive depigmentation with prolonged high-concentration use
Contraindications
Known peptide allergyCaution in pregnancy (limited safety data)
Storage
Store at room temperature, away from direct sunlight and heat. Stable in pH 4–7 formulations. Avoid exposure to air oxidation; prefer airtight packaging.
Clinical Research
- 1.Optimization of Dielectric Material Improves Ionization Capability and Mass Range of Dielectric Barrier Discharge Ionization Mass Spectrometry
Guan X, Wei C, Yan X, Zenobi R · Journal of the American Society for Mass Spectrometry · 2025PubMed Verified
- 2.Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging
Huang ZJ, Zhou XH, Wen WQ, Huang ZT, Xuan J, Gui P et al. · International journal of pharmaceutics · 2024PubMed Verified
- 3.Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway
Chen J, Li H, Liang B, Zhu H · Postepy dermatologii i alergologii · 2022PubMed Verified
- 4.A randomized controlled pilot study of a proprietary combination versus sunscreen in melasma maintenance
Chatterjee M, Neema S, Rajput GR · Indian journal of dermatology, venereology and leprology · 2021RCTPubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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