Gonadorelin

Key Benefits#

• Maintains testicular size during TRT
• Preserves fertility and sperm production during testosterone use
• Stimulates endogenous LH/FSH production
• Maintains HPG axis function during exogenous hormone use
• Used for HCG-free TRT protocols
• Helps restart natural testosterone production (PCT)

Mechanism of Action#

Gonadorelin binds pulsatile GnRH receptors on pituitary gonadotroph cells, stimulating LH and FSH secretion. LH then acts on Leydig cells in the testes to produce testosterone, while FSH maintains Spermatogenesis. Because it requires pulsatile dosing (mimicking the natural ~90-minute GnRH pulse), it maintains the HPG axis activity that is suppressed during TRT. Continuous (non-pulsatile) GnRH stimulation paradoxically desensitizes receptors and suppresses gonadotropins.

Dosing Protocols#

Side Effects#

• Injection site reactions
• Headache
• Nausea at initiation
• Tachycardia (rare)
• Overstimulation if non-pulsatile: temporary gonadotropin suppression

Contraindications#

Avoid continuous (non-pulsatile) dosing as it paradoxically suppresses LH/FSH. Contraindicated with hormonally sensitive tumors. Not for use in women seeking pregnancy without medical supervision.

Storage#

Lyophilized: -20°C. Reconstituted: 4°C, use within 14–21 days. Protect from heat and light.

Featured In Stacks#

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