Chonluten

Key Benefits#

• Supports bronchial mucosal regeneration and repair
• May improve mucociliary clearance in chronic respiratory conditions
• Anti-inflammatory effects on bronchial epithelium
• Pulmonary anti-aging and tissue preservation
• Supports lung function in COPD and chronic bronchitis
• Well tolerated in combination with other Khavinson bioregulators
• Short tripeptide with efficient cellular penetration

Mechanism of Action#

Chonluten's tripeptide sequence Glu-Asp-Leu interacts with gene regulatory regions in bronchial and alveolar cells, normalizing protein synthesis and cellular function. It promotes regeneration of respiratory mucosa, reduces inflammatory gene expression in bronchial tissue, and supports the ciliary function of bronchial epithelium. Its short sequence allows efficient cellular penetration and rapid gene-regulatory activity.

Dosing Protocols#

Side Effects#

• Generally well tolerated
• Mild injection site reactions possible
• No significant adverse pulmonary events reported

Contraindications#

Not FDA approved. Not a substitute for bronchodilators, corticosteroids, or standard COPD therapies. Consult physician for active pulmonary disease.

Storage#

Store at 2–8°C. Protect from moisture and light.

1. 1.
   Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line

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2. 2.
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3. 3.
   Physiological characteristics and cold tolerance of overwintering eggs in Gomphocerus sibiricus L. (Orthoptera: Acrididae)

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4. 4.
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5. 5.
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6. 6.
   Antithrombotic Activity of Brewers' Spent Grain Peptides and their Effects on Blood Coagulation Pathways

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7. 7.
   A Novel High-Molecular-Mass Bacteriocin Produced by Enterococcus faecium: Biochemical Features and Mode of Action

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8. 8.
   Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum

   Fedoreyeva LI, Dilovarova TA, Ashapkin VV, Martirosyan YT, Khavinson VK, Kharchenko PN et al. · Biochemistry. Biokhimiia · 2017PubMed Verified

9. 9.
   Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides

   Fedoreyeva LI, Smirnova TA, Kolomijtseva GY, Khavinson VKh, Vanyushin BF · Biochemistry. Biokhimiia · 2013PubMed Verified

10. 10.
    Peptides tissue-specifically stimulate cell differentiation during their aging

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11. 11.
    Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

    Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF · Biochemistry. Biokhimiia · 2011PubMed Verified

12. 12.
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    Qian ZJ, Jung WK, Byun HG, Kim SK · Bioresource technology · 2008PubMed Verified

13. 13.
    Computational titration analysis of a multiprotic HIV-1 protease-ligand complex

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14. 14.
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18. 18.
    Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease

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19. 19.
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28. 28.
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31. 31.
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32. 32.
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33. 33.
    Cloning and nucleotide sequence analysis of the dog insulin gene. Coded amino acid sequence of canine preproinsulin predicts an additional C-peptide fragment

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34. 34.
    Amino acid sequence of Synechocystis 6714 ferredoxin: a unique structural feature of unicellular blue-green algal ferredoxin

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36. 36.
    Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein

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38. 38.
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    Borin G, Filippi B, Cavaggion F, Marchiori F · International journal of peptide and protein research · 1977PubMed Verified

39. 39.
    Isolation and characterization of a new pancreatic polypeptide hormone

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