Bronchogen

Key Benefits#

• Tissue-specific support for bronchial and lung health
• Promotes normalization of bronchial epithelial cell function
• Potential benefits in chronic bronchitis and COPD support
• Anti-aging effects on pulmonary tissue
• May reduce frequency of respiratory infections
• Supports lung function preservation with aging
• Compatible with other Khavinson bioregulator peptides

Mechanism of Action#

As a short peptide bioregulator, Bronchogen penetrates cell nuclei and interacts with gene promoter sequences in bronchial epithelial cells, acting as a gene expression modulator. It normalizes protein synthesis in bronchial tissue, promotes cellular regeneration, and reduces degenerative changes associated with aging or chronic lung disease. The tetrapeptide sequence Ala-Glu-Asp-Leu is homologous to bronchial tissue proteins, conferring tissue specificity.

Dosing Protocols#

Side Effects#

• Generally well tolerated in research studies
• Mild local reactions at injection site (if injected)
• No significant systemic side effects reported at standard doses

Contraindications#

Not FDA approved. Limited long-term safety data. Use with caution in active respiratory infections or known hypersensitivity to peptide components.

Storage#

Store at 2–8°C. Protect from moisture and light.

1. 1.
   Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum

   Fedoreyeva LI, Dilovarova TA, Ashapkin VV, Martirosyan YT, Khavinson VK, Kharchenko PN et al. · Biochemistry. Biokhimiia · 2017PubMed Verified

2. 2.
   Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology

   Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, Surkova EA, Platonova IS, Titova ON · Bulletin of experimental biology and medicine · 2015PubMed Verified

3. 3.
   Peptides tissue-specifically stimulate cell differentiation during their aging

   Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM · Bulletin of experimental biology and medicine · 2012PubMed Verified

4. 4.
   Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

   Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF · Biochemistry. Biokhimiia · 2011PubMed Verified

5. 5.
   Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability

   Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA et al. · Bulletin of experimental biology and medicine · 2011PubMed Verified