AHK-Cu
Also known as: Copper Tripeptide-3, Alanine-Histidine-Lysine Copper, AHK Copper
AHK-Cu is a copper tripeptide composed of alanine, histidine, and lysine chelated to copper. Distinct from GHK-Cu, AHK-Cu exhibits strong affinity for hair follicle receptors and demonstrates potent hair growth stimulation alongside wound healing and skin regeneration properties.
Half-Life
Hours (topical, variable by formulation)
Route
Topical, Scalp application, Subcutaneous (research)
Category
Skin & Cosmetic, Anti-Aging & Longevity
Studies
1 reference
Key Benefits
- Stimulates hair follicle growth and reduces shedding
- Increases dermal papilla cell proliferation
- Promotes wound healing and skin regeneration
- Antioxidant protection via superoxide dismutase activation
- Improves skin elasticity and firmness
- Supports collagen and elastin production
Mechanism of Action
AHK-Cu binds copper ions and delivers them to tissues requiring metalloenzyme activity. It stimulates vascular endothelial growth factor (VEGF) production, upregulates genes involved in hair follicle proliferation, activates superoxide dismutase, and promotes collagen and elastin synthesis via TGF-β pathways. Its affinity for follicular receptors makes it particularly effective for androgenetic alopecia.
Dosing Protocols
Hair Growth (Topical)
- Dose
- 0.01–0.1% concentration
- Frequency
- Once or twice daily
- Timing
- Applied directly to scalp
- Cycle
- 12–24 weeks
Combine with minoxidil or saw palmetto for synergistic effects. Part hair and apply to scalp; allow to absorb before styling.
Skin Regeneration (Topical)
- Dose
- 0.01–0.05% concentration
- Frequency
- Once daily
- Timing
- Evening application
- Cycle
- Ongoing
Often formulated in serums alongside GHK-Cu for comprehensive copper peptide coverage. Avoid use with strong acids.
Calculate your draw volume
Enter your vial size and BAC water to get exact injection volumes
Side Effects
- Generally well-tolerated topically
- Mild scalp irritation or redness in sensitive individuals
- Possible temporary hair shedding phase at treatment initiation
- Copper accumulation with excessive systemic use (rare)
Contraindications
Known copper sensitivity or Wilson's diseaseActive scalp infections or open woundsPregnancy and breastfeeding (insufficient data)
Storage
Store in a cool, dark location away from light and air. Copper peptide formulations are sensitive to oxidation; use airless pump dispensers when possible. Refrigerate opened products for extended shelf life.
Clinical Research
- 1.The effect of tripeptide-copper complex on human hair growth in vitro
Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC et al. · Archives of pharmacal research · 2007PubMed Verified
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice. Many compounds listed are research chemicals not approved for human use. Always consult a qualified healthcare professional before starting any protocol.
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