Thymalin vs Survodutide
Side-by-side comparison of key properties, dosing, and research.
Immune SupportAnti-Aging & Longevity
ThymalinGLP-1 / Weight Loss Agonists
Survodutide- Summary
- Thymalin is a polypeptide complex isolated from calf thymus glands (developed by the Russian Gerontology Institute), shown to restore immune function, extend lifespan, and reverse thymic involution. Clinical studies demonstrate improved immune parameters and up to 40% reduction in mortality in elderly patients.
- Survodutide is a once-weekly GLP-1/glucagon dual receptor agonist developed by Boehringer Ingelheim and Zealand Pharma. Phase 2 trials demonstrated up to 18.7% body weight reduction at 46 weeks, among the highest reported for a dual agonist. It is being studied for obesity and MASH (metabolic dysfunction-associated steatohepatitis), where the glucagon component drives hepatic fat clearance.
- Half-Life
- Not well characterized as a complex extract; individual peptides have varying kinetics
- ~7 days
- Admin Route
- SubQ, IM
- SubQ
- Research
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- Typical Dose
- 10 mg IM or SC daily
- 0.6 mg → 2.4 mg → 4.8 mg → 6 mg
- Frequency
- Once daily
- Once weekly
- Key Benefits
- Restores thymic function and T-cell immunity
- Extends healthy lifespan (documented in long-term studies)
- Reduces infectious disease incidence in elderly
- Normalizes immune parameters in immunodeficiency
- Anti-tumor immune surveillance
- Improves vaccine response in elderly
- Reduces cardiovascular mortality (40% in landmark Russian study)
- Normalizes neuroendocrine function
- Up to 18.7% body weight reduction at 46 weeks (Phase 2)
- Strong MASH activity — Phase 3 SYNCHRONIZE-NASH trials ongoing
- Reduces hepatic fat content via glucagon receptor-driven liver oxidation
- Once-weekly subcutaneous injection
- Greater weight loss potential than GLP-1 monotherapy
- Improvements in liver fibrosis markers in early data
- Side Effects
- Very well tolerated in decades of Russian clinical use
- Mild injection site reactions
- Rare: mild allergic reaction (natural extract)
- Transient flu-like symptoms on initiation (immune activation)
- Nausea (most common during titration)
- Vomiting
- Diarrhea
- Decreased appetite
- +3 more
- Stacks With
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