TB-500 vs Dermorphin
Side-by-side comparison of key properties, dosing, and research.
Recovery & Repair
TB-500Recovery & Repair
Dermorphin- Summary
- TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring peptide found in nearly all human and animal cells. It promotes cell migration to injury sites, accelerates tissue regeneration, and reduces chronic inflammation.
- Dermorphin is a naturally occurring heptapeptide opioid isolated from the skin of South American phyllomedusine frogs. It is one of the most potent endogenous mu-opioid receptor agonists known, approximately 30-40 times more potent than morphine by weight. Explored for pain management and fatigue modulation.
- Half-Life
- 2–3 hours
- Estimated 30-60 minutes (longer than endorphins due to D-Ala)
- Admin Route
- SubQ, IM
- Subcutaneous (research), Intrathecal (research), Intranasal (research)
- Research
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- Typical Dose
- 2–2.5 mg
- Not established for human use; research doses vary widely
- Frequency
- Twice weekly
- Not established
- Key Benefits
- Enhances muscle tissue regeneration
- Accelerates healing of wounds and injuries
- Reduces inflammation and pain
- Improves flexibility and mobility
- Promotes new blood vessel formation
- Supports hair growth and skin health
- May improve cardiac function after injury
- Systemic healing effect — works at distance from injection site
- Potent analgesia superior to morphine on a per-weight basis
- May reduce perception of fatigue in high-intensity activity
- Longer-lasting than endogenous opioids due to D-amino acid substitution
- Research tool for mu-opioid receptor pharmacology
- Potential therapeutic application in refractory pain
- Side Effects
- Injection site discomfort
- Fatigue (rare)
- Headache (rare)
- High addiction and dependence potential (mu-opioid agonism)
- Respiratory depression at high doses
- Nausea, vomiting, constipation
- Sedation and cognitive impairment
- +2 more
- Stacks With
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