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ToolsCompareMOTS-c vs PE-22-28

MOTS-c vs PE-22-28

Side-by-side comparison of key properties, dosing, and research.

Anti-Aging & Longevity
MOTS-c
Cognitive Enhancement
PE-22-28
Summary
MOTS-c is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. It acts as a metabolic regulator, improving insulin sensitivity, enhancing exercise capacity, and counteracting age-related metabolic decline. It is often called a 'mitochondrial hormone.'
PE-22-28 is a synthetic analog of spadin derived from sortilin, designed to block TREK-1 potassium channels with rapid-onset antidepressant and neurogenic effects. It shows fast-acting depression relief (within 24 hours) and promotes hippocampal neurogenesis.
Half-Life
Estimated 1–2 hours
Relatively short; CNS effects may persist due to neurogenic mechanisms
Admin Route
SubQ
SubQ, Intranasal
Research
Typical Dose
5–15 mg
200–400 mcg
Frequency
3–5 times per week
Once daily
Key Benefits
  • Improves insulin sensitivity and glucose metabolism
  • Enhances exercise capacity and endurance
  • Reduces age-related metabolic decline
  • Activates AMPK — the master metabolic regulator
  • Promotes fat oxidation
  • Anti-inflammatory effects
  • May extend healthspan via mitochondrial optimization
  • Increases energy and reduces fatigue
  • Rapid-onset antidepressant effects (within 24 hours)
  • Promotes hippocampal neurogenesis
  • Improves cognitive performance and memory
  • Reduces anxiety and depressive behavior
  • Novel mechanism — does not act on serotonin/dopamine/GABA receptors directly
  • May help treatment-resistant depression
  • Neuroprotective effects
Side Effects
  • Injection site irritation
  • Fatigue during initial adaptation
  • Unknown long-term profile (limited human data)
  • Generally well tolerated in animal models
  • Limited human data available
  • Possible mild headache or transient mood changes at initiation
  • Injection site reactions (SC)
Stacks With