Humanin vs Palmitoyl Tetrapeptide-7
Side-by-side comparison of key properties, dosing, and research.
Anti-Aging & Longevity
HumaninSkin & Cosmetic
Palmitoyl Tetrapeptide-7- Summary
- Humanin is a mitochondria-derived peptide (MDP) encoded in the 16S rRNA region of the mitochondrial genome. It protects neurons and other cells from apoptosis, improves insulin sensitivity, and declines significantly with age. HNG (S14G-Humanin) is a synthetic analog with 1000x greater potency.
- Palmitoyl Tetrapeptide-7 (Rigin) is a cosmetic peptide consisting of palmitic acid linked to the tetrapeptide sequence GQPR (Gly-Gln-Pro-Arg). It was designed to mimic the biological activity of the IgG immunoglobulin C-terminus, which downregulates the production of interleukin-6 (IL-6), a key driver of skin aging and inflammation.
- Half-Life
- ~4–8 hours (HNG)
- Topical penetration-dependent; effects last hours to days
- Admin Route
- SubQ
- Topical
- Research
- —
- —
- Typical Dose
- 2–8 mg
- 2-5 ppm concentration in formulation
- Frequency
- 3–5 times per week
- Twice daily
- Key Benefits
- Neuroprotection against amyloid-beta toxicity (Alzheimer's relevance)
- Inhibits cellular apoptosis
- Improves insulin sensitivity
- Reduces cardiovascular risk markers
- Anti-inflammatory effects
- Correlates with longevity in centenarian studies
- Protects against ischemic injury
- Potential cancer cell apoptosis sensitization
- Reduces IL-6 inflammatory cytokine in skin
- Prevents 'inflammaging' of the skin
- Inhibits MMP collagen-degrading enzymes
- Synergistic with Matrixyl for anti-aging
- Clinically tested for wrinkle and skin texture improvement
- Well-tolerated topically
- Side Effects
- Injection site irritation
- Limited human safety data available
- Contact sensitization (rare)
- Well-tolerated at standard concentrations
- Stacks With
- —
- —