GHRP-2 vs Palmitoyl Tetrapeptide-7
Side-by-side comparison of key properties, dosing, and research.
Growth Hormone Peptides
GHRP-2Skin & Cosmetic
Palmitoyl Tetrapeptide-7- Summary
- GHRP-2 is a potent synthetic hexapeptide that stimulates growth hormone release by activating ghrelin receptors in the pituitary and hypothalamus. It produces one of the strongest GH pulses among GHRPs, though unlike Ipamorelin it does cause modest increases in cortisol and prolactin.
- Palmitoyl Tetrapeptide-7 (Rigin) is a cosmetic peptide consisting of palmitic acid linked to the tetrapeptide sequence GQPR (Gly-Gln-Pro-Arg). It was designed to mimic the biological activity of the IgG immunoglobulin C-terminus, which downregulates the production of interleukin-6 (IL-6), a key driver of skin aging and inflammation.
- Half-Life
- 15–60 minutes
- Topical penetration-dependent; effects last hours to days
- Admin Route
- SubQ, Intranasal
- Topical
- Research
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- Typical Dose
- 100–300 mcg
- 2-5 ppm concentration in formulation
- Frequency
- 2–3 times daily
- Twice daily
- Key Benefits
- Strong GH pulse stimulation
- Increased IGF-1 levels
- Enhanced muscle growth and recovery
- Improved fat metabolism
- Better sleep quality
- Increased bone density
- Enhanced appetite (less pronounced than GHRP-6)
- Anti-aging effects via GH axis optimization
- Reduces IL-6 inflammatory cytokine in skin
- Prevents 'inflammaging' of the skin
- Inhibits MMP collagen-degrading enzymes
- Synergistic with Matrixyl for anti-aging
- Clinically tested for wrinkle and skin texture improvement
- Well-tolerated topically
- Side Effects
- Increased appetite
- Water retention
- Elevated cortisol (modest)
- Elevated prolactin (modest)
- +2 more
- Contact sensitization (rare)
- Well-tolerated at standard concentrations
- Stacks With
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