Collagen Peptides vs PE-22-28
Side-by-side comparison of key properties, dosing, and research.
Skin & CosmeticRecovery & Repair
Collagen PeptidesCognitive Enhancement
PE-22-28- Summary
- Collagen peptides are short-chain amino acid sequences produced by enzymatic hydrolysis of whole collagen (typically bovine or marine). They serve as bioactive signals that stimulate fibroblasts and chondrocytes to produce new collagen, elastin, and cartilage matrix, supporting skin, joint, bone, and gut health.
- PE-22-28 is a synthetic analog of spadin derived from sortilin, designed to block TREK-1 potassium channels with rapid-onset antidepressant and neurogenic effects. It shows fast-acting depression relief (within 24 hours) and promotes hippocampal neurogenesis.
- Half-Life
- N/A — food-derived; absorbed peptides circulate for hours, depot accumulation in tissues
- Relatively short; CNS effects may persist due to neurogenic mechanisms
- Admin Route
- Oral
- SubQ, Intranasal
- Research
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- Typical Dose
- 10–15 g
- 200–400 mcg
- Frequency
- Once daily
- Once daily
- Key Benefits
- Stimulates skin collagen and elastin production
- Reduces wrinkle depth and improves skin hydration
- Supports joint cartilage regeneration
- Reduces joint pain in osteoarthritis
- Promotes bone density (stimulates osteoblasts)
- Improves gut barrier integrity (leaky gut)
- Supports hair and nail growth
- Excellent amino acid profile for muscle recovery
- Rapid-onset antidepressant effects (within 24 hours)
- Promotes hippocampal neurogenesis
- Improves cognitive performance and memory
- Reduces anxiety and depressive behavior
- Novel mechanism — does not act on serotonin/dopamine/GABA receptors directly
- May help treatment-resistant depression
- Neuroprotective effects
- Side Effects
- Excellent safety profile as food-derived protein
- Rare: bloating or GI discomfort at high doses
- Rare: allergic reaction (bovine or fish allergy)
- Mild bad taste (some forms)
- Generally well tolerated in animal models
- Limited human data available
- Possible mild headache or transient mood changes at initiation
- Injection site reactions (SC)
- Stacks With
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