Collagen Peptides vs ARA-290
Side-by-side comparison of key properties, dosing, and research.
Skin & CosmeticRecovery & Repair
Collagen PeptidesImmune SupportRecovery & Repair
ARA-290- Summary
- Collagen peptides are short-chain amino acid sequences produced by enzymatic hydrolysis of whole collagen (typically bovine or marine). They serve as bioactive signals that stimulate fibroblasts and chondrocytes to produce new collagen, elastin, and cartilage matrix, supporting skin, joint, bone, and gut health.
- ARA-290 is a synthetic 11-amino acid peptide derived from the helix B region of erythropoietin (EPO). Unlike EPO, it selectively activates the innate repair receptor (IRR) without stimulating hematopoiesis, providing tissue protection, anti-inflammation, and neuropathy relief.
- Half-Life
- N/A — food-derived; absorbed peptides circulate for hours, depot accumulation in tissues
- ~2–4 hours (SC administration)
- Admin Route
- Oral
- SubQ
- Research
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- Typical Dose
- 10–15 g
- 4 mg (fixed dose)
- Frequency
- Once daily
- Once daily
- Key Benefits
- Stimulates skin collagen and elastin production
- Reduces wrinkle depth and improves skin hydration
- Supports joint cartilage regeneration
- Reduces joint pain in osteoarthritis
- Promotes bone density (stimulates osteoblasts)
- Improves gut barrier integrity (leaky gut)
- Supports hair and nail growth
- Excellent amino acid profile for muscle recovery
- Reduces neuropathic pain from small fiber neuropathy
- Anti-inflammatory without immune suppression
- Tissue protection after ischemia/reperfusion injury
- Promotes nerve fiber regeneration
- Improves symptoms of sarcoidosis-associated neuropathy
- May reduce insulin resistance and improve metabolic health
- Shown to improve autonomic neuropathy symptoms
- Side Effects
- Excellent safety profile as food-derived protein
- Rare: bloating or GI discomfort at high doses
- Rare: allergic reaction (bovine or fish allergy)
- Mild bad taste (some forms)
- Injection site reactions
- Mild fatigue at initiation
- Transient warm sensation post-injection
- Rare: mild headache
- Stacks With
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